Commentary: Current Advances and Future Directions for CNS Delivery
Journal Title: The AAPS Journal - Year 2008, Vol 10, Issue 4
Abstract
Authors and Affiliations
Craig K. Svensson, Jean-Michel Scherrmann
Keywords
Related Articles
- EP ID EP681623
- DOI 10.1208/s12248-008-9064-1
- Views 85
- Downloads 0
Particle size analysis of concentrated phospholipid microemulsions: II. Photon correlation spectroscopy
The solvated droplet size of concentrated water-in-oil (w/o) microemulsions prepared frome egg and soy lecithin/water/isopropyl myristate and containing short-chain alcohol cosurfactants has been determined using photon...
Blood pressure as an example of a biomarker that functions as a surrogate
There are many important uses of biomarkers in drug development. An area of particular interest is the use of biomarkers as surrogate end points. Only a small minority of biomarkers are established surrogate end points....
Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts
Three advanced models of pharmacokinetics are described. In the first class are physiologically based pharmacokinetic models based on in vitro data on transport and metabolism. The information is translated as transporte...
Inhalation Devices and Patient Interface: Human Factors
The development of any inhalation product that does not consider the patient needs will fail. The needs of the patients must be identified and aligned with engineering options and physical laws to achieve a robust and in...
Performance Comparison of Various Maximum Likelihood Nonlinear Mixed-Effects Estimation Methods for Dose–Response Models
The online version of this article (doi:10.1208/s12248-012-9349-2) contains supplementary material, which is available to authorized users.