Comparative evaluation of the degree of indomethacin crystallinity by chemoinfometrical fourie-transformed near-infrared spectroscopy and conventional powder X-ray diffractiometry
Journal Title: The AAPS Journal - Year 2000, Vol 2, Issue 1
Abstract
A chemoinfometrical method for evaluating the degree of crystallinity based on fourie-transformed near-infrared (FT-NIR) spectroscopy was established and compared with the conventional powder X-ray diffraction method. Powder X-ray diffraction profiles and FT-NIR spectra were recorded for 11 kinds of standard materials with various degrees of crystallinity obtained by physically mixing crystalline and amorphous indomethacin (IMC). Chemoinfometric analysis was performed on the FT-NIR spectral data sets by multiple linear regression (MLR) (MLR-Set-Up Search program). The crystalline and amorphous forms showed significant NIR spectral peaks. MLR analysis was performed based on normalized NIR spectra sets for standard samples of known crystallinity. A calibration equation was determined to minimize the root mean square error of prediction. The predicted crystallinity values were reproducible and had a smaller standard deviation. The values of crystallinity predicted by X-ray powder diffractometry and FT-NIR spectrometry suggested a satisfactory correlation between the 2 techniques. The results indicated that FT-NIR spectroscopy provides for an accurate quantitative analysis of crystallinity compared with conventional X-ray diffractometry.
Authors and Affiliations
Makoto Otsuka, Fumie Kato, Yoshihisa Matsuda
Keywords
Related Articles
- EP ID EP682088
- DOI 10.1208/ps020109
- Views 85
- Downloads 0
Molecular Targets of Dietary Phenethyl Isothiocyanate and Sulforaphane for Cancer Chemoprevention
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis. Conceivably, it can be targeted and interrupted along these different stages. In...
2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook
Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enter...
A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and Citrate Buffer
In the current study, the effect of metal ions in combination with buffers (citrate, acetate, pH 4.5) on the stability of aqueous solutions of oxytocin was investigated. Both monovalent metal ions (Na+ and K+) an...
Population Pharmacokinetic Modeling of LY2189102 after Multiple Intravenous and Subcutaneous Administrations
Interleukin-1 beta (IL-1β) is an inflammatory mediator which may contribute to the pathophysiology of rheumatoid arthritis (RA) and type 2 diabetes mellitus (T2DM). Population pharmacokinetics (PK) of LY2189102,...
A One-Step Solid Phase Extraction Method for Bioanalysis of a Phosphorothioate Oligonucleotide and Its 3′ n-1 Metabolite from Rat Plasma by uHPLC–MS/MS
Oligonucleotide therapeutics have emerged as a promising class of drugs to treat a wide range of diseases caused by genetic abnormalities. Replacement of the phosphodiester linkage with a phosphorothioate is one of the m...