Comparing the Safety and Efficacy of Two Different Synbiotics in the Treatment of Infantile Functional Constipation Resistant to Non-Pharmacological Therapy: A Randomized Clinical Trial
Journal Title: International Journal of Multidisciplinary Research and Analysis - Year 2023, Vol 6, Issue 01
Abstract
Background: Recent evidence emphasizes the positive effect of probiotics and synbiotics in the treatment of functional constipation in childhood, but no study has surveyed the effectiveness of synbiotics in improving the clinical conditions in infants ≤6 months suffering from functional constipation, so we performed this study. Aims: Comparing the efficacy and safety of two types of synbiotics including PediLact® (Zist-Takhmir Co., Tehran, Iran) drop containing Bifidobacterium infantis, Lactobacillus reuteri, Lactobacillus rhamnosus plus fructooligosaccharides with BBCare® (Zist-Takhmir Co., Tehran, Iran) drop containing Bifidobacterium lactis BB-12 plus fructooligosaccharides in the treatment of infantile functional constipation. Study Design: This trial was performed on infants less than 6 months of age who met the ROME IV criteria for infantile functional constipation. The patients were randomly assigned to receive PediLact drop (n = 44) or BB-Care drop (n = 45) for one month and were evaluated on the seventh day and at the end of the first month. Results: A significant downward trend was revealed in the responsive rate of every clinical symptom in both intervention groups but BB-Care was more effective than PediLact in improving the frequency of weekly defecation. Both synbiotics also improved significantly all symptoms of constipation in all types of feeding methods after one week and one month of intervention (primary outcomes). There was no side effect of synbiotics through intervention (secondary outcome). Conclusions: This study shows that both synbiotics improved significantly all symptoms of functional constipation after one week and one month of intervention apart from type of feeding method in infants less than 6 months of age. Due to the greater effectiveness of BB-care in increasing stool frequency, B. lactis may play a more prominent role in this age group. This study has been registered at the Iranian Registry of Clinical Trails (IRCT20160827029535N7).
Authors and Affiliations
Niloufar Ghanbari, Peymaneh Alizadeh Taheri , Kambiz Eftekhari
Keywords
Related Articles
- EP ID EP712987
- DOI 10.47191/ijmra/v6-i1-11
- Views 106
- Downloads 0
Support Mechanisms for Orphans’ Academic Achievement in Tanzania
Orphans access to education is still critical for most of developing countries and Tanzania specifically. There have been government efforts such as policy and progams development and implementation to ensure orphans acc...
The Implementation of Project-Based Learning Models and Learning Behavior to Improve Economic Learning Achievement through Learning Motivation
This research aims to analyze the influence of Project-Based Learning models and Learning Behavior on Economic Learning Achievement through Learning Motivation in Grade XII Social Science at SMA N 3 Bantul. The type of r...
Improving the Endurance of the Lower Body Muscles Strength with the Application of Chair Media to Athletes Long Distance Running Numbers of KONI in Depok City
This study aims to increase the endurance strength of the lower body muscles with the application of seat media to athletes who run long distance running numbers in Depok City KONI athletes. The research sample was 30 at...
Possible Solutions to Challenges of Including Learners with Special Educational Needs in Mainstream Classrooms
As a major strategy towards the achievement of basic education for all, Lesotho introduced free and compulsory primary education, whereby many children were sent to school. The mountain kingdom of Lesotho implemented the...
An Ecolexicon on Poul Poul in Toba Batak Language of Toba Dialect in Aek Kanopan: An Ecolinguistic Study
One of the important things that must continue to be explored and maintained is the richness of the ecolexicon of a tradition, culture, and customs. This research is about the Ecolexicon Treasures of Poul Poul in Toba Ba...