Comparison of Dexmedetomidine and Magnesium Sulphate to assess neuroendocrine response using blood glucose as a marker in laparoscopic Cholecystectomy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Anaesthesia and surgery induced stress response can be modulated by premedication drugs.This study was done to assess the extent of stress attenuation by using dexmedetomidine and magnesium sulphate premedication by analyzing perioperative variation in bloodglucose level during laparoscopic cholecystectomy under general anaesthesia.In a prospective blind study,90 ASA1 patients who were posted for elective laparosopic cholecystectomy under general anaesthesia were divided into three groups .Group D patients (n =30) were given intravenous dexmedetomidine 1μgm/kg , Group M patients (n =30) received magnesium sulphate 30mgm/kg ,Group C patients (n =30) were given normal saline over a 10 min period ,before induction of anaesthesia.Hemodynamic parameters like heartrate,MAP were assessed. Anaesthesia and surgical techniques were standardized.Peroperative blood glucose values were assessed preoperatively, 30 min and 1 hour after beginning of surgery.Both premedicants attenuated hemodynamic and neuroendocrine stress response of pneumoperitoneum and general anaesthesia.The dexmedetomidine group showed better intraoperative stability and blood glucose control on comparison to magnesium sulphate group.During laparoscopic cholecystectomy,dexmedetomidine and magnesium sulphate have effectively modulated neuroendocrine stress response of general anaesthesia as analyzed by blood glucose variation, but dexmedetomidine was better
Authors and Affiliations
Vairavarajan Chandrasekaran, Prathima Sharon Jayaraj
Keywords
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- EP ID EP239287
- DOI 10.9790/0853-1610037780
- Views 100
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