Comparison of erythrocyte sedimentation rate and C-reactive protein levels (literature review and own data)
Journal Title: Український терапевтичний журнал - Year 2019, Vol 0, Issue 2
Abstract
Erythrocyte sedimentation rate (ESR) and C-reactive protein (C-RP) are used for the diagnosis and control of the treatment in the course of inflammatory conditions, moreover they can provide an understanding of the disease pathophysiological basis. Objective — to assess the state of the problem of ESR and C-RP usage based in the literature data and own clinical observations. Materials and methods. The literature review of the data in PubMed database and Ukrainian sources has been performed. Besides, the analysis has been performed on the set of own results of the examination of 373 patients with hemorrhagic vasculitis, rheumatic fever, acute forms of coronary heart disease (CHD), divided into comparable groups depending on the condition of the gall bladder (GB). Data were processed using Statistica 6.0 software; results were considered significant if p < 0.05. Results and discussion. In the serological diagnosis of acute diseases, the preference was given to C-RP which is produced by liver for the recognition and elimination of foreign pathogens, endotoxins, necrotized or apoptotic cells. At acute inflammatory conditions C-RP may be increased up to 50—100 mg/l for 4—6 hours after affecting by pathogenic stimulus. The ESR begins to rise later, within 24—48 hours after the onset of inflammation. The frequency of discordant changes in ESR and C-RP among all hospitalized patients is 12 %. The minimal ESR values were reveled in patients with CHD, for whom coronary artery bypass grafting was planned, in subjects with intact GB (12.71 ± 1.75) mm/hr) and folded gallbladder (9.92 ± 1.10) mm/h), and maximal ESR was in case of hemorrhagic vasculitis (19.18 ± 2.95) mm/h). The mean C-RP level in patients with hemorrhagic vasculitis was 2.5 times higher than normal value (7.51 ± 1.22) mg/l). The C-RP levels were the highest in patients with rheumatic fever (19.57 ± 4.36) mg/l, p < 0.05). Conclusions. Changes in ESR and C-RP are not parallel, thus the analysis of both parameters is required. The discordant changes in ESR and C-RP may be stipulated by nosology, age, gender, presence of obesity, GB condition. The GB condition affects the severity of systemic inflammation, which is maximal in the case of post-inflammatory deformations of GB neck, signs of chronic cholecystitis, cholelithiasis, and history of cholecystectomy. Changes in ESR and C-RP can often be discordant, including case of rheumatic fever and hemorrhagic vasculitis.
Authors and Affiliations
L. M. Strilchuk
Acetylsalicylic acid in the cardiological practice: the focus on enterotoxicity
Acetylsalicylic acid (ASA) is one of the most commonly prescribed drugs all over the world. The constant ASA administration results in the considerable side effects, especially associated with the gastrointestinal tract....
Peculiarities of the heart failure course in patients with non-toxic goiter: clinical aspects
Objective — to investigate peculiarities of the heart failure (HF) course in patients with non-toxic goiter (NG). Materials and methods. Examinations involved 222 patients with HF (with previous myocardial infarction (MI...
Galectin 3 — a novel biomarker for chronic heart failure in the patients with ischemic heart disease and concomitant gastroesophageal reflux disease
Objective — to study the role of the biomarker for chronic heart failure (CHF) Galectine 3 (Gal 3) in patients with IHD and concomitant gastroesophageal reflux disease (GERD). Materials and methods. The study involved 10...
Polymorphous variants А1166C of АТІІR1 gene in patients with cardiovascular pathology
The review presents analysis of the role of the polymorphic variant of gene of type 1 receptors to the angiotensin II (A1166C polymorphism of ATIIR1 gene) in the arterial hypertension, heart failure, myocardial infarctio...
The model of adverse course of heart failure with account of the thyroid status of patients
Objective — to determine the predictors of adverse course of heart failure (HF) with account of the thyroid status of patients. Materials and methods. The study involved 157 patients with HF (and previous myocardial infa...