Comparison of Ketamine and Propofol in Combination with Fentanyl and Midazolam in Total Intravenous Anaesthesia for Minor Gynecological Procedures
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 2
Abstract
Background: Total intravenous anesthesia (TIVA) is commonly employed for anesthetizing patients for minor gynecological procedures such as dilatation and curettage. Aim: The aim of this study is to compare the effectiveness of ketamine and propofol in combination with fentanyl and midazolam in TIVA for minor gynecological procedures. Materials and Methods: This is a prospective randomized study of 20 patients of ASA physical status 1 or 2 divided into two groups. One group received TIVA with propofol, fentanyl, midazolam, and glycopyrrolate whereas the other group received TIVA with ketamine, fentanyl, midazolam, and glycopyrrolate. Hemodynamic parameters, oxygen saturation during anesthesia, and adverse effects if any were noted and recorded during a 15 min interval after administration of the induction drug. Results: A signifi cant increase in heart rate and blood pressure responses were observed during a 15 min interval period following ketamine administration for induction compared to propofol. There were instances of desaturation (SpO2 < 92%) in 4 cases belonging to propofol group which was treated with jaw thrust and bag and mask ventilation with O2 support. Conclusion: Ketamine produced an adequate plane of anesthesia with minimal side effect profi le than propofol when combined with other agents in TIVA.
Authors and Affiliations
V Krithika, R Amudharani, Heber Anandan
Keywords
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