Condition of the proteolytic system in patients with tuberculous pleurisy
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2019, Vol 0, Issue 2
Abstract
Recently, extrapulmonary forms of tuberculosis are increasingly common, which are not related to the pulmonary system. The largest proportion of extrapulmonary forms is pleural tuberculosis. This disease in case of delayed therapy can lead to prolongation of a specific process as a various forms of pulmonary tuberculosis and its extrathoracic localization. Objective — investigate the condition of the proteolytic system on the example of neutrophil elastase (NE) in patients with acute and chronic form of tuberculous pleurisy, including when combined with pulmonary tuberculosis. Identify possible pathogeneticconnections between the level of neutrophil elastase and chronic tuberculous pleurisy. Materials and methods. We observed 45 patients with tuberculous pleurisy, the main manifestation of which was the syndrome of pleural effusion of different localization. Patients were divided into two groups. In Group I, 26 (57.7 %) patients with acute course of tuberculous pleurisy were involved, in Group II, 19 (42.2 %) patients with chronic tuberculous pleurisy. The study of the proteolytic system was carried out by determining the activity of neutrophil elastase in the blood serum by spectrophotometric method. The control group consisted of 16 individuals (12 men and 4 women) who did not have the disease at the time of the study. The elastase level in this group averaged 75.0 nmol/(min · mL), it was considered normal. Results and discussion. In patients with an acute process during hospitalization, the level of neutrophil elastase ranged from 62.5 to 309.8 nmol/(min · mL) (on average — (160.8 ± 18.2) nmol/(min · mL), that is exceeded the norm by 2.1 times (p < 0.05)), in patients with chronic tuberculous pleurisy — from 183.4 to 351.6 nmol/(min · mL) (on average — (255.5 ± 15.5) nmol/(min · mL), that is, exceeded the norm by 3.4 times (p < 0.05)). Comparison of neutrophil elastase in acute and chronic tuberculous pleurisy revealed that in patients with a chronic specific process, its content was 1.6 times higher (p < 0.05). Conclusions. Researchers allowthat a significant increase in the level of neutrophil elastase, during hospitalization of a sick person, with chronic tuberculosis pleurisy may be a manifestation of both stimulation of the patient’s defenses against the tuberculosis process in general, and stimulation of productive proliferative processes on the one hand. On the other hand, it may be a specific marker of tuberculous pleurisy and a sign of its chronicity, which is a direct indication for surgical intervention.
Authors and Affiliations
I. D. Duzhiy, G. P. Oleshchenko, I. A. Hnatenko, V. O. Oleshchenko
Keywords
Related Articles
- EP ID EP673976
- DOI 10.30978/TB2018-2-41
- Views 85
- Downloads 0
Extrapulmonary tuberculosis and miliary tuberculosis in patients with TB/HIV co-infection. Part 2
-
Some clinical and epidemiological aspects of survival in patients with HIV infection on the background of antiretroviral therapy
Objective — to analyze the factors that affect the survival of patients with HIV infection in patients receiving antiretroviral therapy (ART). Materials and methods. A retrospective study on the effect of antiretroviral...
A study of the informative value of the histological research of biopsy material for the etiology of pulmonary dissemination
Objective — to determine the diagnostic standards according to the criteria — sensitivity (informative), specificity (diagnostic value) and accuracy (effectiveness) of the histological diagnostic method for verifying the...
The newly detected pulmonary sarcoidosis in HIV-infected patients
Objective — to determine the clinical, X-ray examination features in the newly detected sarcoidosis in HIV-infected patients. Materials and methods. Data of 6 HIV-infected patients (3 women, 3 men, middle age 42.4, rang...
Extrapulmonary tuberculosis and miliary tuberculosis in patients with TB/HIV co-infection. Part 3
-