Some clinical and epidemiological aspects of survival in patients with HIV infection on the background of antiretroviral therapy
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 1
Abstract
Objective — to analyze the factors that affect the survival of patients with HIV infection in patients receiving antiretroviral therapy (ART). Materials and methods. A retrospective study on the effect of antiretroviral therapy have been conducted on the survival of patients with HIV infection over 6 years (2010—2016). The study group included 450 patients with established HIV infection, who were prescribed various ART regimens during 2009—2010. Results and discussion. We have identified factors that affect the prognosis of ART. The main ones were opportunistic infections, comorbid states and the level of immunosuppression before the start of therapy. Analysis of opportunistic infections and comorbid conditions revealed predominance of such as Herpes Zoster, oropharyngeal candidiasis, toxoplasmosis, cytomegalovirus infection, as well as coinfection with HIV/TB and HIV/hepatitis, with the prevalence of HCV associated hepatitis. Among the 11 patients who died in the first year of therapy, only 1 patient had a CD4+ T lymphocyte level of more than 300 cells/ml, while the remaining CD4+ levels were < 200 cells/ml. Conclusions. Thus, it can be seen that the survival of HIV infected patients is affected by a variety of risk factors for death, such as the level of primary CD4+ T lymphocytes, drug use, chronic hepatitis, tuberculosis, and etc. It can also be assumed that the maximum reduction in the mortality of HIV infected patients is possible only when each of these risk factors is affected.
Authors and Affiliations
L. R. Shostakovych-Koretska, О. V. Sheveleva, O. P. Shevchenko-Makarenko
Characteristics of HIV-associated diseases of the central nervous system in hospitalized patients in the Dnipropetrovsk region
Objective — to analyze the main epidemiological, demographic and laboratory characteristics of cases of HIV associated diseases of the central nervous system (CNS) in the Dnipro city and Dnipropetrovsk region in the peri...
Palliative care for co-infection with tuberculosis/HIV. Part 3
-
Tuberculosis and HIV co-infection in inpatients of phthisio-pulmonological profile: frequency, form of lesion, diagnostic features (according to data of highly specialized institution)
Objective — to clarify the prevalence of tuberculosis infection in HIV-positive inpatients of the TB hospital for 2014—2018 and features of its diagnosis in the affection of the chest cavity organs. Materials and method...
Effect of antituberculosis treatment on dynamics of carbohydrate and lipid profile
Objective — study the effect of antituberculosis treatment on the dynamics of carbohydrate and lipid profile in patients with newly diagnosed pulmonary tuberculosis Materials and methods. We examined 76 patients with dr...
Condition of the proteolytic system in patients with tuberculous pleurisy
Recently, extrapulmonary forms of tuberculosis are increasingly common, which are not related to the pulmonary system. The largest proportion of extrapulmonary forms is pleural tuberculosis. This disease in case of delay...