Some clinical and epidemiological aspects of survival in patients with HIV infection on the background of antiretroviral therapy
Journal Title: Туберкульоз, легеневі хвороби, ВІЛ-інфекція - Year 2018, Vol 0, Issue 1
Abstract
Objective — to analyze the factors that affect the survival of patients with HIV infection in patients receiving antiretroviral therapy (ART). Materials and methods. A retrospective study on the effect of antiretroviral therapy have been conducted on the survival of patients with HIV infection over 6 years (2010—2016). The study group included 450 patients with established HIV infection, who were prescribed various ART regimens during 2009—2010. Results and discussion. We have identified factors that affect the prognosis of ART. The main ones were opportunistic infections, comorbid states and the level of immunosuppression before the start of therapy. Analysis of opportunistic infections and comorbid conditions revealed predominance of such as Herpes Zoster, oropharyngeal candidiasis, toxoplasmosis, cytomegalovirus infection, as well as coinfection with HIV/TB and HIV/hepatitis, with the prevalence of HCV associated hepatitis. Among the 11 patients who died in the first year of therapy, only 1 patient had a CD4+ T lymphocyte level of more than 300 cells/ml, while the remaining CD4+ levels were < 200 cells/ml. Conclusions. Thus, it can be seen that the survival of HIV infected patients is affected by a variety of risk factors for death, such as the level of primary CD4+ T lymphocytes, drug use, chronic hepatitis, tuberculosis, and etc. It can also be assumed that the maximum reduction in the mortality of HIV infected patients is possible only when each of these risk factors is affected.
Authors and Affiliations
L. R. Shostakovych-Koretska, О. V. Sheveleva, O. P. Shevchenko-Makarenko
Keywords
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