CONGENITAL HYPOTHYROIDISM: CURRENT PERSPECTIVESCONGENITAL HYPOTHYROIDISM: CURRENT PERSPECTIVES
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 7
Abstract
Thyroid hormones are key essential factors for the development of the fetal and neonatal brain. A disease of the thyroid gland, congenital hypothyroidism occurs due to a partial or complete loss of function resulting in thyroid hormone deficiency. Present at birth, incidence of CH is gradually increasing worldwide, with an estimated prevalence of 1:2,000 to 1:4,000. This may be due to several factors like population ethnicity, varying screening programs and differing TSH cut-off values and environmental influences. It is also seen to affect more pre-terms and low birth weight new-borns than term neonates. It is one of the most common endocrine disorders in paediatric age group and if left untreated may result in growth failure and halted intellectual impairment. However, it still largely remains an underrated problem in many parts of the world due to lack of routine new born screening (NBS) programs. The aim of these programs include early detection of congenital hypothyroidism and an optimal neurocognitive outcome. American academy of paediatrics recommend treatment with levothyroxine (initial dose of 10-15μgm/kg/day) and this should be initiated within two weeks of life. The main aim of treatment is to normalize T4 levels within 2 weeks and TSH levels within one month and ensure positive growth and neurodevelopmental outcomes with no hindrance to their genetic potential. This article aims at the current outlook on congenital hypothyroidism and its management.
Authors and Affiliations
He Bing Yan
Keywords
Related Articles
- EP ID EP673635
- DOI -
- Views 170
- Downloads 0
THE POSSIBILITIES OF MOLECULAR-BIOLOGICAL MARKERS IN SUPPRODUCTIVE IMMUNOTHERAPY IN PATIENTS WITH ONCINE-INTAL DISEASES
The aim of the study was to study the expression of molecular biological tumor markers in patients with cervical cancer and ovarian cancer, and their effect on the course of accompanying immunotherapy. It was shown that...
ANTICALCIC EFFECT OF AN AQUEOUS TRUNK BARK EXTRACT OF PARKIA BIGLOBOSA (JACQ. BENTH (MIMOSACEAE) ON THE SPONTANEOUS CONTRACTILE ACTIVITY OF THE ISOLATED HEART OF RAT
Objective: Parkia biglobosa (Mimosaceae) is a plant used in African traditional medicine to treat hypertension and heart disorders. Cardiac activity is underlain by particularly calcium ionic flow through the myocardial...
EFFECT OF COPPER OXIDE NANOPARTICLES ON THE SPLEEN OF ADULT MALE ALBINO RAT AND THE POSSIBLE PROTECTIVE ROLE OF VITAMIN C HISTOLOGICAL STUDY
Background: Copper oxide nanoparticles (CuO NPs) have attracted attention mostly because of their antimicrobial and biocide properties. Despite their high application potential, there are various disadvantages of CuO NPs...
ASSESSMENT OF OMEGA-3 FATTY ACIDS COMPOSITION AND LIPID CONTENT FROM LIVER, MUSCLE AND CAVIAR OF ACIPENSER PERCICUS
Sturgeons are commercially the most important fish species in the world. Marine animals such as fish provide Omega-3 fatty acid EPA and DHA, which are mostly promoted for their protective effects on our heart. In the pre...
METHYLENETETRAHYDROFOLATE REDUCTASE C677T GENE POLYMORPHISM IN PSORIASIS IN CHINESE HAN POPULATION
Objective: A study to evaluate gene polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene C677T that exists in cases with psoriasis in the Chinese Han population with a view to find linkage of risk. Metho...