Creatinine estimation by compensated Jaffe method and enzymatic method - A comparative study
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 1
Abstract
Background: Chronic Kidney Disease is a global threat to health particularly for developing countries, since therapy is expensive and life-long. Incidence of CKD has doubled in the last 15 years. Accurate creatinine measurement is essential in the diagnosis of chronic kidney disease as serum creatinine is used for estimating glomerular filtration rate. The aim of our study was to compare the analytical performance between the enzymatic method and compensated Jaffe method for estimation of creatinine. Methods: In our study we measured serum creatinine in 135 serum samples by both enzymatic and compensated Jaffe methods using Cobas c311 automated analyser. Results: Relationship between both the methods using Cobas c311 automated analyser showed a correlation coefficient of 0.999, which means these two methods correlate very well. Conclusion: There was a good agreement and comparability between compensated Jaffe and enzymatic methods except for a minimal variation at higher concentrations of creatinine.
Authors and Affiliations
D Merriwin, P M Abraham Sam Rajan, N Ananthi
Keywords
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