DESIGN AND IN VITRO EVALUTION OF SUSTAINED RELEASE FILM COATED TABLETS OF VERAPAMIL HYDROCHLORIDE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
An attempt was made to formulate the sustained release tablet of verapamil hydrochloride by using the wet granulation method for the treatment of hypertension. In the present formulation the tablets releases the loading dose by immediate drug release and maintenance dose up to 15 hours by extended release. The drug excipient compatability study was carried out with HPLC method and there was no interaction found. Immediate release fraction was formulated by using croscarmellose sodium as a disintegrating agent and extended release fraction was formulated by using Hypromellose E4 as a rate controlling polymer. The granules were evaluated for pre and post compressional character which showed satisfactory results. In vitro dissolution study was carried out for 15 hrs using USP dissolution apparatus type II with 0.1 N HCl and 7.4 pH phosphate buffer as dissolution medium. From the dissolution profile, F2 & F3 values were calculated which were within the specification. Stability study was carried out for the optimized formulation at 40°C/75% RH for 1 month, the result showed that there was no significant change in physical and chemical parameter of the tablet.
Authors and Affiliations
BS Venkateswarlu, B Jaykar, Pasupathi A, R Margret Chandira, Palanisamy P
Keywords
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