DESIGN, EVALUATION AND COMPARITIVE STUDIES OF ORAL THIN FILMS AND EDIBLE GEL LOADED WITH ANTI HISTAMINE DRUG FOR GERIATRICS AND PEDIATRICS
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
The Aim of present study is to Design, Evaluate & Compare studies between fast dissolving Oral thin films (OTF) & Edible gel (EG) loaded with Antihistamine drug for Geriatrics and Pediatrics. The Anti-Histamine Drug called Desloratadine is a tricyclic antihistamine, which has a selective and peripheral H1-antagonist action used to treat allergies. Twelve Formulations (F1–F12) of OTF were prepared by casting method using different concentrations of polymers i.e, Sodium alginate (1, 1.5, 2w/v %) and Xanthum (0.4, 0.7w/v %), as the conc. of polymer increased tensile strength and folding endurance were improved with more dissolution time. Ten Formulation (EG1-EG10)of EG were prepared by varying concentrations of Gellan Gum (0.1-0.5%), 0.3% and above concentration of polymer showed good physical and Rheological properties. Optimized Formulation among OTF was F4 with 1.5% Sodium alginate showing good folding endurance, tensile strength, disintegration time and 98.9% drug release with no casting problem and appearance. Optimized formulation among EG was EG8 with no syneresis showing 99% drug release with good consistency and viscosity increasing the mouth feel. Comparative study parameter of F4 and EG8 clearly revealed the instability of OTF and stability of EG at room temperature and also due to its high patient compliance based on appearance and ease of administration, EG was preferred as better dosage form for geriatrics and paediatrics.
Authors and Affiliations
Venkata Anupama M , R. Shireesh Kiran , V. Uma Maheswar Rao
Keywords
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