DEVELOPMENT OF HYDROPHILIC MATRIX TABLET OF CARBAMAZEPINE USING 33 FULL FACTORIAL EXPERIMENTAL DESIGNS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: The study aims at developing the hydrophilic matrix tablet of carbamazepine (CBZ) using an optimization technique. The purpose of the study was to develop the hydrophilic matrix dosage form using the combination of different viscosity grades of hydroxypropyl methylcellulose (HPMC) to get the release within the desired target dissolution profile (TDP).Methods: A full factorial design was employed to develop once a day matrix tablet using hydrophilic matrix polymers like HPMC K4M (X1), HPMC K15M (X2) and HPMC K100M (X3) as independent variables and the percent drug release at 1h (Y1), 8h (Y2) and 20h (Y3) was considered as dependent variables. The optimization and the design space were obtained using response surface methodology and multiple response optimization using the polynomial equation.Results: The result indicates that concentration of all the three polymers plays an important role in the release of the drug for 24h. The formulated tablets have good physical properties and the optimized formulation prepared using design space showed the release within the target dissolution profile and followed zero order release pattern.Conclusion: The results demonstrated that design of an experiment can be used to develop hydrophilic matrix dosage form with the desired drug release properties.Â
Authors and Affiliations
Shashikant Barhate, Maria Husain
Keywords
Related Articles
- EP ID EP578903
- DOI -
- Views 91
- Downloads 0
INVESTIGATION OF BIOGENIC SILVER NANOPARTICLES GREEN SYNTHESIZED FROM CARICA PAPAYA
Objective: This work mainly focuses on the investigation of optical, structural and morphological characteristics of Silver nanoparticles (Ag-NPs) synthesized using Papaya (Carica Papaya) leaf extract and to study the me...
COMPARISON OF FT-NIR TRANSMISSION AND HPLC FOR GREEN APPROACH TO DETERMINE PARACETAMOL AND ITS DEGRADATION PRODUCT 4-AMINOPHENOL IN PARACETAMOL TABLETS
Objective: Development and validation of Near infrared (NIR) spectroscopic method for determination of paracetamol and its major degradation product 4-aminophenol in paracetamol tablets and show the agreement between the...
LYOPHILIZATION OF SOLID LIPID NANOPARTICLES FOR BRAIN TARGETING
Objective: The aim of this work is to investigate formulation and process parameters that could impact freeze drying of loperamide-loaded Solid Lipid Nanoparticles (Loperamide loaded SLN).Methods: Loperamide loaded SLN w...
ANTITESTICULAR ACTIVITY OF HYDRO-METHANOL EXTRACT OF CUMINUM CYMINUM IN ADULT RAT: A DOSE DEPENDENT STUDY
Objective: The present study was to evaluate the dose-dependent effects of Cuminum cyminum (C. cyminum) on testicular gametogenic and androgenic activities in adult rat.Methods: The hydro-methanolic extract was administ...
EVALUATION OF PROBIOTIC AND ANTIMICROBIAL PROPERTIES OF LACTOBACILLUS STRAINS ISOLATED FROM DAIRY PRODUCTS
Objective: Evaluation of antimicrobial efficacy of probiotic Lactobacillus strains isolated from dairy products.Methods: The study used yogurt sample prepared from raw buffalo milk to isolate Lactobacillus strains by fol...