Differential Expression of Toll-like Receptors and Antimicrobial Peptides in the Patients with Sézary Syndrome and Idiopathic Erythroderma
Journal Title: Journal of Dermatology Research - Year 2025, Vol 6, Issue 2
Abstract
Erythroderma, characterized by the presence of erythematous patches and plaques affecting more than 80% of the body surface, is a manifestation of different cutaneous and systemic diseases [1]. Up to 20% of patients may remain undiagnosed thus characterizing Idiopathic Erythroderma (IE) [2]. Sézary Syndrome (SS) is an erythrodermic and leukemic variant of cutaneous T-cell lymphoma [3]. Moreover, sepsis from bacterial infections have been identified as a significant cause of mortality among these patients [4]. Toll-Like Receptors (TLRs) responsible for recognizing bacterial components (TLR2, TLR4, TLR5 and TLR9), along with the Antimicrobial Peptides (AMP), including Human Beta-Defensin (HBD) and Cathelicidins (CATH) play a significant role in the innate cutaneous immunity.
Authors and Affiliations
Amadeu José Rodrigues Queiróz, Kelly Cristina Gomes Manfrere, Naiura Vieira Pereira, Marina Torrealba, Denis Ricardo Miyashiro, Mirian Nocagami Sotto, Maria Notomi Sato*, José Antonio Sanches
Keywords
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- EP ID EP768491
- DOI https://doi.org/10.46889/JDR.2025.6207
- Views 11
- Downloads 0
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