Dissolution of lithium carbonate from three types extended-release capsules in paddle, basket and flow-through apparatus
Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2012, Vol 25, Issue 2
Abstract
Current Issues in Pharmacy and Medical Sciences Vol. 25, No. 2, Pages 164-167 Three types of 24-h extended-release multiparticulate capsules containing a dose of 480-504 mg lithium carbonate in a form of either pellets or 2 mm minitablets or 6 mm tablets were prepared. Dissolutions tests were performed using three different pharmacopoeial apparatus: basket, paddle and flow-through apparatus. Only capsules filled with pellets showed the same dissolution profiles, irrespective of the apparatus used in the study. In the case of two other formulations, the slowest dissolution occurred in the flow-through apparatus. The largest difference between release profiles from different apparatus was observed for the capsule filled with 6 mm tablets. The observations may indicate that probability of good reproducibility of dissolution profiles obtained in different test conditions, including change of apparatus, is related to either size or a number of the units in a capsule.
Authors and Affiliations
Malgorzata Sznitowska, Pawel Pietkiewicz, Agnieszka Dorosz, Jerzy Lukasiak, An Vermeire, Jean Remon
Keywords
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