Does central IL-1β affect GnRH secretion in the hypothalamus of anoestrous ewes via different regulatory pathways?
Journal Title: Journal of Animal and Feed Sciences - Year 2013, Vol 22, Issue 1
Abstract
The study was designed to identify the central pathways through which central interleukin-1β (IL-1β) affects gonadotropin-releasing hormone (GnRH) release in anoestrous ewes. Our results show that intracerebroventricular (icv.) injection of IL-1β (50 μg) decreases the GnRH concentration in the perfusates collected from the medial basal hypothalamus/median eminence (MBH/ME), increases its type I receptor gene expression in the preoptic area, anterior hypothalamus (AHA) and medial basal hypothalamus, and significantly decreases the neuropeptide Y (NPY) mRNA level in the AHA and MBH. No effect of IL-1β treatment was found on plasma cortisol concentration, catecholamine (norepinephrine and dopamine) levels in perfusates, as well as cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) gene expression in the hypothalamus. Our data demonstrate that central IL-1β suppresses GnRH release mainly by acting directly through its own hypothalamic receptors, and its effect could be, at least partially, caused by changes in the NPY level, which is known as an important modulator of GnRH biosynthesis and release.
Authors and Affiliations
Dorota Tomaszewska-Zaremba, Andrzej Przemysław Herman, Tomasz Misztal
Keywords
Related Articles
- EP ID EP72902
- DOI -
- Views 127
- Downloads 0
Chemical composition, antioxidant activity and bioactive compounds of vegetation species ingested by goats on semiarid rangelands
The first goal of this study was to evaluate the chemical composition of vegetation consumed by goats on semiarid rangelands. Secondly, antioxidant activity and identified bioactive compounds of this vegetation were esti...
Plant extract enhanced ruminal CLA concentration, in vitro
The effect of adding plant extracts to ruminal fluid on the formation of conjugated linoleic acid (CLA) isomers and on fermentation parameters was evaluated. Initially, fifteen plant extracts at two levels (1 and 2 mg ·...
Responses of mammary amino acid metabolism and aminopeptidase N gene expression to duodenal soyabean small peptides and infusion of free amino acids in lactating goats
The duodenal perfusion technique was used to determine whether small peptides were more effective than free amino acids (FAA) for milk protein synthesis and to investigate the effects of infusing soyabean small peptides...
Effects of replacing fish meal with ensiled catfish (Pangasius hypophthalmus) by-products on the performance and carcass quality of finishing pigs
Thirty castrated finishing male pigs were used to evaluate the effects of replacing fish meal (FM) with ensiled Tra catfish (Pangasius hypophthalmus) by-products (ECM) on performance and carcass quality. Pigs were alloca...
Influence of grain processing in regard to serum metabolites and enzymes for finishing bull calves
This study compared two grain processing methods that are widely used for beef cattle, grinding and steam pelleting, with respect to serum metabolic parameters: glucose, non-esterified fatty acids (NEFA), serum urea nitr...