Effect of Quail Egg Yolk on the Formulation and Characterisation of Self Emulsifying Drug Delivery Systems of Simvastatin
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 7
Abstract
SEDDS are mixtures of oil, surfactant and co-surfactant which are emulsified in aqueous media under conditions of mild agitation and digestive motility that are encountered in the gastrointestinal (GI) tract. The aim of this study was to develop a novel formulation of SEDDs using simvastatin which is a poorly water soluble drug. The study was conducted by preparing SEDDS with moringa oleifera, tween 80 (surfactant), egg yolk (surfactant) and polyethylene glycol (co-surfactant). After screening of various vehicles (oil, surfactant and co-surfactant) based on better drug solubilising power, liquid SEDDS were formulated. Prepared formulation were characterized on the basis of self emulsification ability, emulsification time, phase separation, spontaneity of formation, viscosity. Among the 8 formulations prepared, 4 of the formulations comprising formulations A1- A4, showed very good and promising characteristics when analysed using different parameters. All the formulations recorded emulsification time below 1 min which showed a very good performance as it agreed with the study were 2 mins was used as an evaluation index by some researchers in the emulsification process. The use of quail egg yolk helped in the reduction of emulsification time drastically in the formulations. Also the quail egg yolk used reduced the viscosity of the formulation in that it helped to reduce inter facial tension of the formulations making the formulations more flowable. In drug loading, the drug was well absorbed in all the formulations with formulations A1, showing the highest drug content of 93%. In other to avoid unstable systems thermal stability test was conducted on the selected SEDDS and all the 4 formulations were found to be stable at different temperature conditions as there was no phase separation, no creaming or cracking. Cloud point determination showed that all the formulations had their cloud points above 850C which shows that the formulations are stable at physiological temperature.
Authors and Affiliations
Osemeahon S, Onyirioha N. N
Keywords
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