Effect of vitamin D supplementation in children with severe acute malnutrition in a nutritional rehabilitation centre: a randomized controlled trial

Abstract

Background: According to World Health Organization (2013) approximately 35% of the under-fivemortalities are due to nutrition related factors & 4.4% of deaths are due to severe wasting. It has been found that Vitamin D levels are low in children with malnourished and very sick children. Even the prevalence of vitamin D deficiency is very high in Indian subcontinent. In WHO recommendations for the management of severe acute malnutrition there is no role of vitamin D supplementation. Objective: To study the effect of vitamin D supplementation on severe acute malnourished children admitted in nutritional rehabilitation Centre. Design: Single blinded Randomized controlled, parallel group trial. Setting: Nutritional Rehabilitation Centre (NRC) of a tertiary care hospital. Participants: 70 severe acute malnourished children aged 6 months to 59 months admitted in the NRC were randomized by computer generated random table. Intervention: 6 lakhs IU vitamin D was given intramuscularly on day one of therapy after an informed consent to the study group and other group was given only management of SAM. Main Outcome measure: outcome indicators of NRC i.e. cure rate, death rate, non-responders, relapse rate. Results: There was no significant difference in the outcome indicators of NRC i.e cured, death, non-response and relapse rate (p=0.32) and average weight gain (p= 0.38) and length of stay (p=0.42) between the two groups at discharge but wasting (p=0.02 on first, p=0.008 on third and p=0.04 on fourth follow ups respectively) improved significantly on follow ups. Conclusions: vitamin D supplementation does not have any significant improvement in the outcome indicators at discharge but significantly improves wasting on follow up.

Authors and Affiliations

Keywords

Related Articles

Clinical profile and outcome of dengue among hospitalized children - a single centre prospective study

Introduction: Dengue is the most rapidly spreading mosquito-borne viral disease in the world.In India, there is increased proportion of Dengue cases with severe disease. Early recognition and prompt initiation of appropr...

Clinical profile of childhood Guillain-Barre Syndrome

Objective: Recognizing the clinical presentation of Guillain–Barre syndrome in children. Design: Retrospective observational study. Setting: Pediatric wards and Paediatric Intensive Care Unit. Method: A medical record fi...

A study on growth profiles in children with thalassemia major between 2-10 years of age on regular transfusions and oral chelation therapy

Introduction: Thalassemia patients require regular blood transfusions to maintain haemoglobin level around 10gm/dl, which results in transfusional iron over load which is treated by well-established parenteral desferriox...

Prospective study on cord bilirubin level as a predictor of Hyperbilirubinemia in term healthy neonates

Introduction:Neonatal jaundice or hyperbilirubinemia is a cause of concern for parents and pediatricians, with more than 60% being affected by this condition in the first few weeks. Prediction of high risk neonates for h...

Patterns of health care for children with asthma: A qualitative study

Background: Many children across the world, struggle with asthma, especially when the condition worsens due to lack of adherence to treatment strategies, the reason for which however may not be completely understood. Hen...

Download PDF file
  • EP ID EP375471
  • DOI 10.17511/ijpr.2018.5.07
  • Views 158
  • Downloads 0

How To Cite

(2018). Effect of vitamin D supplementation in children with severe acute malnutrition in a nutritional rehabilitation centre: a randomized controlled trial. Pediatric Review: International Journal of Pediatric Research, 5(5), 278-283. https://www.europub.co.uk/articles/-A-375471