Effects of Quercetin Loaded Magnetic Nanoparticles on Electrophysiological and Behavioural Disturbances in the Animal Models of Epilepsy
Journal Title: The 1st Annual Meeting of Georgian Center for Neuroscience Research - Year 2020, Vol 2, Issue 20
Abstract
Epilepsy is one of the most common neurological disorder, characterized by repetitive seizures and various mental health problems. Currently more than 30% of epilepsy cases are resistant to the treatment. It is believed that the basic cause of the disease is the disbalance between the excitatory and inhibitory processes in neurons. In modern research one of the major candidates for new antiepileptic drug development are flavonoids-plant derived antioxidants. In our project we focused on Quercetin, which is the member of polyphenol flavonoid family with antiinflammatory and antioxidant characteristics, but with low bioavailability. We studied Quercetins influence on the hippocampal electrophysiological activity and behavioural disturbances in the lab rats with status epilepticus caused by kainic acid. To overcome and increase the low bioavailability of quercetin we loaded it with nanoparticles and after injection in the tail of the lab rat, animals were placed under the unilateral magnetic field directed on the temporal lobe. Electrophysiological recordings revealed that injection of Quercetin loaded nanoparticles with the presence of hippocampus projected magnetic field significantly changes the amplitude and frequency of epileptiform discharges in the hippocampus. Behavioural and morphological analysis are still in progress..
Authors and Affiliations
Gia Kutelia, Nanuli Doreulee
Keywords
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- EP ID EP677951
- DOI 10.29088/GCNR-2020.42
- Views 222
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