Epidemiology, risk factors and prognosis of Interferon alpha induced thyroid disorders. A Prospective Clinical Study

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2017, Vol 71, Issue

Abstract

Introduction: Hepatitis C virus (HCV) infection is a worldwide problem and hepatitis, which is its natural unfavourable course, is still a challenge for hepatologist. At present, standards of treatment are changing from combined therapy with interferon alpha (IFN-α) and ribavirin to new antiviral drugs. The current classification divides interferon induced thyroid diseases (IITD) into two groups: autoimmune (Hashimoto disease, Graves disease, positive antithyroid autoantibodies in euthyroid patients) and non-autoimmune (destructive thyroiditis, non-autoimmune hypothyroidism). A common complication of cytokine therapy is the induction of antithyroid autoantibodies de novo without thyroid dysfunction. During therapeutic regimens combined with ribavirin, destructive thyroiditis with typical biphasic course is more common than in IFN-α monotherapy. Clinically, overt pathologies often have discrete symptoms, which cause diagnostic and therapeutic dilemmas. Aims: The aim of this study was to estimate IITD occurrence, to find risk factors for IITD development. Material and methods: The study group consisted of 66 patients treated for HCV infection. Before and during antiviral therapy, hormonal (TSH, fT4, fT3), immunological (thyroid autoantibodies), ultrasonographic and genetic (HLA-A2) parameters were evaluated. Results: Hormonal disturbances were detected in 24.2% of patients; however, 43.9% of patients had positive thyroid autoantibodies (de novo) without hormonal imbalance. Multivariate analysis revealed the following: female sex, elevated TSH level, occurrence of anti-TPO autoantibodies (TPO-Ab), and increased blood velocity in thyroid arteries are risk factors for IITD development. In conclusion: Thyroid disorders are common during IFN-α therapy. Previous epidemiological data seem to be underestimated. Important risk factors for IITD development are: female sex, elevated serum TSH concentration (≥2.5 μU/mL), positive TPO-Ab and increased blood velocity in thyroid arteries.

Authors and Affiliations

Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak

Keywords

Related Articles

Czy stężenie cystatyny C w surowicy jest lepszym markerem czynności nerek niż stężenie kreatyniny u noworodków z sepsą?

Wprowadzenie: Wyniki opublikowanych badań dowodzą, że oznaczanie cystatyny C w surowicy może stanowić lepszy marker czynności wydalniczej nerek niż stężenie kreatyniny w surowicy. Jednakże znaczenie tego markera w diagn...

Prokalcytonina (PCT), współczesny wskaźnik infekcji i stanów zapalnych

Prokalcytonina jest białkiem syntetyzowanym w odpowiedzi na zakażenie. Jej wytwarzanie w tych stanach jest stymulowane przez mediatory reakcji zapalnej oraz toksyny bakteryjne. Rutynowe oznaczanie stężenia PCT jest przyd...

Zespoły paranowotworowe a choroby reumatyczne

Zespoły paranowotworowe, którym poświęcona jest praca, są grupą heterogenicznych zaburzeń związanych z chorobami nowotworowymi, ale nie są bezpośrednio spowodowane przez fizyczne skutki guza pierwotnego lub jego przerzut...

Milk-derived proteins and peptides in clinical trials

Clinical trials are reviewed, involving proteins and peptides derived from milk (predominantly bovine), with the exception of lactoferrin, which will be the subject of another article. The most explored milk fraction is...

Download PDF file
  • EP ID EP223268
  • DOI 10.5604/01.3001.0010.4782
  • Views 175
  • Downloads 0

How To Cite

Łukasz Obołończyk, Małgorzata Siekierska-Hellmann, Piotr Wiśniewski, Anna Lewczuk, Monika Berendt-Obołończyk, Zofia Michalska, Danuta Radowska, Grażyna Moszkowska, Agnieszka Bianek-Bodzak, Krzysztof Sworczak (2017). Epidemiology, risk factors and prognosis of Interferon alpha induced thyroid disorders. A Prospective Clinical Study. Advances in Hygiene and Experimental Medicine, 71(), 842-849. https://www.europub.co.uk/articles/-A-223268