Estimation of Lactate Dehydrogenase Activity in cerebrospinal fluid in different types of meningitis
Journal Title: International journal of Advanced Biological and Biomedical Research - Year 2017, Vol 6, Issue 1
Abstract
Objective: Meningitis is life-threatening condition and examination of the Cerebrospinal fluid (CSF) may not give a precise diagnosis and prognosis of different types of meningitis. Bacterial meningitis is still a very common problem especially in many developing countries. The aims of study are to estimate the importance and significance of Lactate Dehydrogenase (LDH), protein and sugar in CSF of different types of meningitis. Methods: A total of 160 cases, aged between 1 month and 60 years, including patients with bacterial meningitis (n=50), pyogenic meningitis (n=46), viral meningitis (n=24) and a control group (n=40), were analyzed on the basis of data from the initial clinical examinations. Results: Significant increase in LDH level (P<0.001) were observed in the test group when compared to the control group. The LDH activity was significantly elevated in the CSF and serum (p < 0.001) in cases of pyogenic (PM) as well as tuberculosis meningitis (TBM). Bacterial meningitis is more common than non bacterial meningitis. The enzymatic activity of LDH although significantly raised in PM compared to TBM but there was no cutoff level to differentiate them. The LDH level did rise quite significantly in pyogenic meningitis.
Authors and Affiliations
Ranbeer kumar Singh| Department of Microbiology Narayan Medical College and Hospital, Jamuhar, Sasaram, Bihar, Farhan Usmani| Department of Biochemistry, Patna medical college and Hospital, Patna, India, Syed Shahzadul Haque| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India, Md. Tanweeruddin| Department of Anaesthesiology and Critical Care, ECR, Danapur, Baban Kumar Singh| Department of Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Keywords
Related Articles
- EP ID EP13579
- DOI 10.18869/IJABBR.2017.412
- Views 426
- Downloads 34
The Effect of Group Learning (Discussion) and Individual Learning Progress in Reading Performance of Dyslexic Students in Second Grade in 2016-17, Qazvin City
Objective: This study aims to review group learning method effect compared to individual learning method on dyslexic students of second grade in elementary school and it evaluates whether their problem will be solved i...
The effect of irrigation regimes and n-fertilizer levels on developmental time and parameters of fecundity life table of spodoptera exigua (hubner) on sugar beet
The beet armyworm, Spodoptera exigua, is one of the most important pests of sugar beet in Iran. The aim of this study was to determine the effect of water and nitrogen treatments of sugar beet plant on developmental ti...
Evaluation of maximum light absorption and light extinction coefficient in different levels of nitrogen and wheat cultivars
The experimental was split plot in a randomized complete block design with three replications. In this experiment, different levels of nitrogen in the main plots included four levels (0, 50, 100 and 150 N) kg.ha-1 urea...
Effects of Dietary Marshmallow (Althaea Officinalis L.) Extract on Growth Performance and Body Composition of Common Carp (Cyprinus Carpio)
Objective: This study was conducted to evaluate the effects of different proportions of marshmallow extract (Althaea officinalis L.) on growth performance and carcass composition of common carp (Cyprinus carpio). Metho...
Evaluation of Antioxidant Activity of Methanolic Extract of Elaegnus Angustifolia by Frap Assay
Nowadays the researches have indicated the fact that using synthetic antioxidants as food additives in edible oils can have adverse effects on human health. So preparing antioxidation resources for reduction of oxidation...