Eugenol efficacy in preventing nicotine-induced seizures in mice
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 11
Abstract
Background: Seizure is the most common neurological disorder after stroke. In fact, the seizure is a chronic neurological disorder affected 1-2% of the global population. Given the side effects and toxicity of synthetic drugs, some herbal medicines are currently used in the treatment of seizure. Aims and Objectives: The aim of this study was to evaluate the effect of Eugenol, a compound extracted from clove plant, which is effective in preventing nicotine-derived seizures in mice. Materials and Methods: In this study, 64 mice were randomly selected. In the dose-response study, different doses of Eugenol (400, 600, and 800 mg/kg) were intraperitoneally injected to the experimental groups. The negative and positive control groups, respectively, received saline (10 ml/kg) and diazepam (0.15 mg/kg). After 30 min, the animals in all groups received intraperitoneal injections of nicotine (5 mg/kg) followed by the measurements of onset time, duration, and severity of seizures. In time-response examination, the most effective dose of Eugenol (600 mg/kg) was injected into the animals at 15, 30, 45, and 60 min before nicotine injection. Afterward, the onset, severity, and duration of seizure were determined. Results: The results of the dose-response test showed that Eugenol doses of 400, 600, and 800 mg/kg resulted in increased time of onset, and reduced severity and duration of seizure compared to the saline group. The results of time-response revealed that the best dose was 600 mg/kg and that the best time for Eugenol injection was in 30 min before injection of nicotine. Conclusion: The results of this study suggest that Eugenol can be effective in controlling nicotine-induces seizures.
Authors and Affiliations
Neda Sistani Karampour, Ardeshir Arzi, Soroor Namazifar
Keywords
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- EP ID EP292166
- DOI 10.5455/njppp.2017.7.0623110072017
- Views 71
- Downloads 0
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