Evaluation Antioxidant and Antibacterial Activities of n-Butanol Fraction of Conocarpus Erectus L. Leaves Extract
Journal Title: International Journal of Pharmaceutical and Medicinal Reserach - Year 2016, Vol 4, Issue 6
Abstract
N-butanol extract of Conocarpus erectus L. leaves was studied for antioxidant and antibacterial activities. In vitro systems for example, 1, 1- diphenyl-2 picrylhydrazyl (DPPH) radical, and antioxidant capacity (Ferric Reducing Antioxidant Power, FRAP assay). The antibacterial activity was determined using the hole-in-plate agar diffusion. The extract scavenged DPPH radicals comparable with ascorbic acid and butyl hydroxytoluene (BHT). The n-butanol extract of Conocarpus erectus L. leaves showed high free radical scavenging activity toward DPPH radical between (29.87-79.33). The n-butanol extract had radical scavenging activity less than the Ascorbic acid (34.61-80.76) and butyl hydroxytoluene (BHT) (33.33-66.66). The results indicated the antioxidant capacity of butanol extract had a significantly (0.50-1.11nm) much higher than ascorbic acid (0.5-0.86nm ) and butyl hydroxytoluene (BHT) (0.30-0.76nm). Antibacterial activity was found to be present in nbutanol extract of Conocarpus erectus L. leaves being highest in Straptococcus (22mm). Zones of inhibition for E.coli, Staph. aureus and Enterobacter were 21, 20 and 19 respectively. Results show plants to possess antibacterial activity.
Authors and Affiliations
Rawa A. Hussein
Cardiotoxicity associated with chemotherapy: Need for treatment and prophylaxis role
Cardiotoxicity is a well-known potential side effect of several chemotherapeutic agent. Patients undergoing chemotherapy highly exposed to cardiac complications. Chemotherapeutic agents like anthracycliines, cyclophosp...
Biography
Dr. V. K. Gupta has more than 12 Years teaching experience. Presently, working as a Director Principal [Approved by Himachal Pradesh Technical University, Hamirpur] at Dreamz College of Pharmacy, Khilra, Sunder Nagar...
Synthesis and Antimicrobial Activity of 5-{4'-[(4"-aryl)- -3"-cyano 2"-ethoxy pyridine-6"- yl] phenyl carbamido}-dibenz [b,f] azepines derivatives
The titled compounds (4a-4k) have been synthesized by the condensation of 5-{4'-[(3"-aryl)-2"- Propene-1"-one]-Phenyl carbamido}-dibenz [b,f] azepines with malononitrile and Sodium ethoxide. The biological activities o...
Incretins: based therapy for type-2 Diabetes mellitus (T2DM)
The treatment of type 2 diabetes mellitus is metformin and sulfonylurea (SU) as first-line anti- diabetic therapies for many years. It is the first line treatment though the combination results in a progressive declin...
Particle coating: From conventional to advanced
Powder particle coating is the most important technique in pharmaceutical industry. It has constantly being refined and modified since last four decades. There are numerous applications of coating, including drug laye...