Evaluation of anticonvulsant activity of stem bark extract of Tephrosia purpurea
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
The anticonvulsant potential of Ethanolic extract of stem bark extract of Tephrosia purperia was evaluated in albino mice. The ethanolic extract of stem bark extract of Tephrosia purperia (200 mg/kg and 400 mg/kg), was studied for their anticonvulsant effect on maximal electroshock induced seizures (MES) and pentylenetetrazole (PTZ) induced seizures in mice. The duration of hind limb tonic extension in case maximal electroshock induced seizures and onset of convulsions in case of pentylenetetrazole induced seizures were noted. The percentage mortality was calculated. Tephrosia purperia significantly reduced the duration of seizures by MES. The effect of Tephrosia purperia PTZ induced convulsions was not marked. The data suggest that the ethanolic extract of Tephrosia purperia will produce its anticonvulsive effect by acting on voltage dependent sodium ion channels since it reduced the duration of seizures produced by maximal electroshock.
Authors and Affiliations
N. S. Murali Krishna, K. Appanna Chowdary
Keywords
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