Evaluation of hypoglycemic activity of aqueous extract of bark of Ficus bengalensis linn. in alloxan induced diabetic rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
Objective: Evaluation of Hypoglycemic activity of Extract of bark of Ficus bengalensis Linn. In alloxan induced diabetic albino rats and comparison with standard drug Glibenclamide. Methods: Aqueous extract of bark of Ficus bengalensis was evaluated for hypoglycemic activity. Albino rats were divided into five groups of six-animals each. Diabetes was induced by using Alloxan monohydrate (180mg/kg.b.w:i.p).control group was treated with normal saline 0.5; second group was treated with Glibenclamide 5mg/kg as a standard drug. Remaining 2 groups were treated with different doses (150 & 300mg/kg.b.w) of bark of F.bengalensis for a period of 28 days. Fasting glucose level estimated by using Glucometer on days 3, 7, 14, 21 and 28. Results: An Aqueous Extract of F.benglensis Linn. produced significant regulation of fasting blood glucose in diabetic rats. At the dose of 300mg/kg showed significant fall in blood glucose level as compared to 150mg/kg.b.w. Post-prandial reduction of blood glucose levels on day 3 after 3hrs of drug administration was significant (p value< 0.07) with bark 300mg as compared to other doses. This is however, highly significant (p value<0.0001) when compared with standard drug Glibenclamide Conclusions: Further study can be evaluated for its potential antidiabetic activity.
Authors and Affiliations
Arati Chikaraddy, Yasmeen A Maniyar
Keywords
Related Articles
- EP ID EP33441
- DOI -
- Views 327
- Downloads 0
FORMULATION AND EVALUATION OF CAPTOPRIL MICROENCAPSULES: A SUSTAINED RELEASE APPROACH
The aim of the present study is to formulate and evaluate Captopril micro-encapsules. Microspheres and micropellets of captopril prepared with different polymers through the techniques of microencapsulation were found...
ADR MONITORING IN HYPERTENSION OUT PATIENT DEPARTMENT OF HOSPITAL
Adverse drug reactions (ADRs) to anti-hypertensive agents are common and can lead to noncompliance or even discontinuation of therapy. There is paucity of such data in the Indian context. We deemed it worthwhile to ass...
A review of various analytical methods on Atrovastatin
There is a review of analytical methods for atorvastatin, such as spectrophotometry, derivative spectrophotometry and various chromatographic procedures such as, high-performance liquid chromatography (HPLC), high-perf...
A VALIDATED RP-HPLC METHOD FOR THE ESTIMATION OF BACLOFEN IN BULK DRUG AND PHARMACEUTICAL FORMULATIONS
A new, simple, specific, sensitive, rapid, accurate and precise RP-HPLC method was developed and validated for the estimation of Baclofen in bulk drug and pharmaceutical formulations. Baclofen was chromatographed on a...
Cardio protective activity of Passiflora foetida extract and silver nanoparticles in doxorubicin induced cardiac disease in rats
Medicinal plants have been observed to possess numerous activities with regard to cardiovascular system viz. antiplatelet, hypolipidemic, anti-inflammatory, hypoglycemic and hypotensive actions. For cardiovascular dise...