EXPRESSION OF SMAD2TUMOR SUPPRESSOR GENE IN COLORECTAL CANCER: RETROSPECTIVE STUDY
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 12
Abstract
Background: Colorectal cancer (CRC) defined as the cancerous growths in the colon, rectum and appendix. It is a commonly diagnosed cancer in both men and women and represents the third most common form of cancer and the second leading cause of cancer-related death in the western world, SMAD2 (SMAD family member 2) is a protein-coding gene. It is a tumor suppressor gene located at 18q21 a region commonly deleted in colon adenocarcinomas, The role of Smad2 gene as an important tumor-suppressor gene emphasizes the complexity of rate-limiting check points in human tumorigenesis. Most of Smad2 gene mutations in human cancer are missense, nonsense, and frame shift Mutations at the mad homology2 region (MH2) which interfere with the homo-oligomer formation of Smad4protein and hetero oligomer formation between Smad4 and Smad2proteins, resulting in disruption of TGF-b signaling to thousands of adenomatous polyps in colon and rectum. Authors aimed to investigate the clinical significance of SMAD2 in colorectal cancer progression. Materials and methods: Expression of SMAD2 was detected in 50 formalin fixed paraffin using quantitative PCR (QPCR) and their levels were analyzed versus clinicopathological factors of CRC patients. Results: Significant relation was reported young female and CRC as compared to their counterparts from male individuals. SMAD2 Expression was increased significantly with old CRC and reported significant correlation with advanced stage and high grade tumors. Conclusion: SMAD2 expression was significantly related to differential grading thus pointing out their potential role as predictive markers for CRC prognosis.
Authors and Affiliations
Prof. Hatem El Mezean
Keywords
Related Articles
- EP ID EP639938
- DOI -
- Views 147
- Downloads 0
THE NEONATAL MORTALITY IN TERTIARY HOSPITAL (BAGHDAD TEACHING HOSPITAL): RISK FACTORS
Background: The neonatal period (first 28 days of life) is the most critical time for a child’s survival. Neonatal mortality risk factors are complex, relatively improved slowly, but remains a major concern in developing...
TEAM BASED LEARNING - ORIENTATION OF TEACHING FACULTY TO TBL IN THE TBL MODE, IN A CARIBBEAN MEDICAL SCHOOL.
Aim: The present paper is a report on how the teaching faculty at a Caribbean medical school in Aruba was oriented to the TBL strategy before implementation to students. Method: Sixteen teaching faculty, most of whom wer...
PHYTOCHEMICAL SCREENING, ANTIBACTERIAL ACTIVITY AND GC/MS ANALYSIS OF OIL FROM SUDANESE OKRA
This investigation was carried out, for phytochemical screening and to study the chemical constituents of Sudanese Okra Abelmoschusesculentus Oil and to assess its potential antibacterial activity. Preliminary phytochemi...
EFFECTIVE TREATMENT OF TYPE II DIABETES BY USING PELLETS MANUFACTURED BY EXTRUSION AND SPHERONIZATION TECHNIQUE
Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, producing hyperglycemia resulting from a defect in insulin secretion, insulin action, or both. Type 2 diab...
COMPARATIVE STUDY OF THE BIOSYNTHESIS OF PROTEINS OF RAT LIVER MITOCHONDRIA AT PHYSIOLOGICAL AGING AND THE MODEL OF “ACCELERATED AGING”, INFLUENCE ON THIS INDICATOR OF SOME PLANT PREPARATIONS
It has been determined that quercetin and its supramolecular complex have the ability to stimulate the translation processes in mitochondria of rat liver in the model of “accelerated aging”, as well as rats of different...