Features of nephropathy in obese patients with type 2 diabetes mellitus
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 2
Abstract
Background. The article describes the results of the studies of diabetic nephropathy in obese patients with type 2 diabetes mellitus (DM). The aim of the study is to investigate the combination of obesity and renal pathology in patients with type 2 diabetes mellitus. Materials and methods. The study included 50 patients with type 2 DM (17 men and 33 women), mean age 58.5 ± 7.0 years treated at the Republican Specialized Scientific and Practical Centre of Endocrinology in 2014–2016. The patients were randomized into 2 groups: with obesity (BMI > 30 kg/m2; n = 38) and without it (BMI < 30 kg/m2; n = 12). Exclusion criteria included manifested diabetic nephropathy (DN) (glomerular filtration rate (GFR) below 60 ml/min/m2, albuminuria over 2 g/24 hr), hematuria, acute cardiovascular events less than last 6 month ago, age over 70 years. Anthropometric parameters included body mass index, waist and hips circumference, waist-to-height ratio. Serum creatinine, uric acid, triglycerides levels, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glycosylated hemoglobin were determined. Severity of renal pathology was estimated by GFR and albumin excretion in urine. Results. Prevalence of hyperfiltration, microalbuminuria and proteinuria increased in patients with obesity (15, 26.6, 50 %, respectively) compared to the patients without obesity (8, 11, 11 %, respectively) when the DM duration over 5 years. Patients with BMI > 30 kg/m2 more frequently presented higher blood pressure levels (arterial hypertension stage 3 in 13 %), enhanced uric acid and reduced low-density lipoprotein cholesterol level (55.1 %) than the patients with BMI < 30 kg/m2. Conclusions. The obese patients with type 2 DM and obesity (BMI > 30 kg/m2) more frequently had renal pathology than non- obese patients. It suggests an independent role of obesity in the development of DN in addition to specific mechanisms of renal pathology in diabetic patients. This effect of obesity is mediated through the enhancement of hemodynamic and metabolic disorders.
Authors and Affiliations
S. U. Ahmedova, Z. S. Kadyrova
Keywords
Related Articles
- EP ID EP176317
- DOI 10.22141/2224-0721.13.2.2017.100609
- Views 63
- Downloads 0
The Importance of Clinical and Diagnostic Markers of Aggression of Non-Functional Pituitary Adenomas
Sixty patients with non-functional pituitary adenomas were observed. Most patients had large-cell chromophobe pituitary adenomas (81.6%). Small-cell chromophobe adenomas occurred in 10 % cases. Only 1 patient (3.3 %) had...
Screening of abdominal obesity and diabetes mellitus in women with oncological diseases
Background. The purpose of the study was to assess the presence of excess body weight, abdominal obesity (AO), and type 2 diabetes mellitus (DM) in oncological diseases in women of young and middle age. Materials and met...
Сarbohydrate Metabolism Disorders and Metabolic Syndrome Components in Patients with Essential Hypertension Associated with Physiological and Postsurgical Menopause
The objective — to compare the characteristics of carbohydrate metabolism, and the presence of other components of metabolic syndrome (MS) associated with physiological and postsurgical menopause, as well as the assessme...
Gonarthrosis and Coxarthrosis on the Background of Diabetes Mellitus
Osteoarthritis has a great medical, social and economic influence on the society, and the most topical problem is considered to be knee and hip joint diseases, since gonarthrosis (GA) and coxarthrosis (CA) are the most d...
Clinical Case of Newly Diagnosed Hypoglycemic Paroxysm Complicated by Severe Neurological Disorders
The paper presents a case of hypoglycemic paroxysm, manifested as epilepsy, in 53-year-old man, suffering from diabetes mellitus type 1, complicated by steatohepatosis following excretory and endocrine pancreatic insuffi...