FORMULATION AND CHARACTERISATION OF MELOXICAM LOADED EMULGEL FOR TOPICAL APPLICATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 11
Abstract
Objective: The aim of the research work is to formulate emulgel of Meloxicam for topical application.Methods: The method used for preparation of microemulsion was water titration method with Oleic acid as oil phase, Tween 20 as surfactant and PEG 400 as co-surfactant and its concentrations were fixed based on Pseudoternary phase diagrams. The optimized emulsion formulation was incorporated into the gel matrix that is Carbopol981 NF and Carbopol 974 P NF.Results: The prepared emulsions were characterized for globule size, drug content, zeta potential and the emulgel for physical appearance, drug content, pH, viscosity, spreadability, extrudability and in vitro drug release studies. The optimized emulsion formulations E1 and F1 showed globule size of 176 nm and 128 nm respectively and the emulgel formulation M2F1 with 1.5% Carbopol 981 and optimized F1 emulsion formulation showed in vitro drug release of 89.934% at the end of 8 h. The optimized formulation showed no skin irritation when compared with standard irritant 0.8% of Formalin. The optimized formulation showed better anti-inflammatory effect when compared with marketed formulation.Conclusion: Meloxicam was proven to be a suitable candidate for formulating emulgel for topical delivery to achieve better patient compliance.Â
Authors and Affiliations
Arti Pednekar, Panchaxari Dandagi, Anand Gadad, Vinayak Mastiholimath
Keywords
Related Articles
- EP ID EP578157
- DOI -
- Views 87
- Downloads 0
IN SILICO MODELLING OF β-LACTAM RESISTANT ENTEROCOCCUS FAECALIS PBP4 AND ITS INTERACTIONS WITH VARIOUS PHYTO-LIGANDS
Objective: The resistance to β-lactam antibiotics is a serious problem worldwide. This resistance has emerged due to two main mechanisms: production of β-lactamases that hydrolyses β-lactam antibiotics and other is th...
FLAVONOIDS FROM SUGAR BEET LEAVES AS HEPATOPROTECTIVE AGENT
Objective: This work was designed to investigate the activity of Beta vulgaris (B. vulgaris) extract against hepatotoxicity induced by (carbon tetrachloride) CC14 in male rats.Methods: Hepatoprotective study was performe...
CRYSTAL STRUCTURE PREDICTION IN THE CONTEXT OF PHARMACEUTICAL POLYMORPH SCREENING AND PUTATIVE POLYMORPHS OF CIPROFLOXACIN
Molecular simulation is increasingly used by medicinal chemists in the process and product development. Reliable computational predictions are of great value not only for the design of an active pharmaceutical ingredient...
CANAL DISH (CD), THE NEW ANTIMICROBIAL TESTING APPARATUS
Objective: This writing aims to introduce new antimicrobial test apparatus called Canal Dish (CD), theoretically.Methods: We have designed two types of CD such as Circular CD (CCD) and Square CD (SCD). Internally, the CC...
APPLICATION OFF-LINE SPE-HPLC/UV METHODS IN ANALYSIS OF OFLOXACIN IN HUMAN URINE (IN VITRO)
Objective: The objective of this study is to determine the validity of analytical methods in OFX antibiotic study in human urine (in vitro) using an SPE-HPLC/UV. In this study, SPE was applied in preparing the analysis o...