FORMULATION AND EVALUATION OF BUCCAL TABLET OF SALBUTAMOL SULPHATE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Mucoadhesive tablets containing salbutamol sulphate were prepared using direct compression method. Carbopol 934P, HPMC K4M, and xanthan gum were used as bioadhesive polymer. HPMC K4M and Xanthan gum were used in different ratios. The tablets were evaluated for their physical characteristics like thickness, hardness, friability, weight variation, uniformity of content, surface pH, Ex vivo mucoadhesion time, in vitro swelling study, in-vitro bioadhesion study and in-vitro drug release pattern. Tablet exhibited extended release for a period of six hours. The mechanism of drug release was found to be non-fackian diffusion and followed the first order kinetic. Increased of carbopol 934 P delayed the release rate. Swelling index was calculated with respect to time. Swelling index increased as the weight gain by the tablets increased proportionally with the rate of hydration. Optimized tablets (F8) showed satisfactory results by adhesive strength of 10.9 ±1.1 g and Ex vivo mucoadhesion time of 9 h. The surface pH of all batches was between 6 to7 and hence tablets should not caused irritation in buccal cavity. Formulation batches containing carbopol 934 P lowered the drug release as compared to other batches. The optimized formulation was subjected to three different aggreavated condition of temperature 0-4ºC, at RT and at temperature 45ºC for two months. The effect of temperature study revealed there was no significant change observed in two months.
Authors and Affiliations
Atul Chaudhari , Leena Jagtap , Aniruddha Mahajan , Sima Swami , Prabha Mali
Keywords
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