FORMULATION AND EVALUATION OF GLIMEPIRIDE PATCHES FOR TRANSDERMAL DRUG DELIVERY
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 6
Abstract
Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, less side effect, easy use and improved patient compliance. Glimepiride is an anti-diabetic drug with a shorter half life of ~5 hours, low bioavailability and extensive first pass metabolism due to these limitations required to maintain the therapeutic level it has chosen as transdermal drug delivery system.The present study was to formulate and evaluate transdermal drug delivery system of Glimepiride using polymers such as HPMC & Eudragit RS100 by solvent casting technique. Central composite design (CCD) was applied by using design-expert to optimize composition of HPMC and ERS100 for Transdermal Drug Delivery. The prepared formulations were evaluated for different physicochemical characteristics like Weight Variation, Folding Endurance, Flatness, pH of patches, % Moisture Content, % Moisture uptake, % Elongation, % Drug Content & % Drug Release. The drug release characteristics of the formulation were studied in-vitro by using semi-permeable membrane. The in-vitro drug release plot showed that the drug release followed zero order kinetics & Higuchi model, which was evidenced from the regression values. Based on the drug release and physicochemical values obtained from the formulation F3 is considered as an optimized formulation which shows higher percentage of drug release (97.33±0.26% at 24 hour) with diffusion mediated mechanism. Korsmeyer-Peppas exponential plots shows fairly linear add, it is well supported by their regression coefficient values & slope values (n) were more than 1 which suggest that drug was released by Super Case-II transport.
Authors and Affiliations
RAHUL SHIVAJIRAO SOLUNKE*| Research Scholar, PRIST University, Vallam, Thanjavur-613403. Tamilnadu, India, PRAVEEN D. CHAUDHARI| PES’S Modern College of Pharmacy, Nigdi, Pune-411044. Maharashtra, India.
Keywords
Related Articles
- EP ID EP3793
- DOI -
- Views 472
- Downloads 31
Bedaquiline: A Novel Addition to Anti-Tubercular Armamentarium
In current scenario of rising trend of resistant tuberculosis (TB) and acquired immunodeficiency syndrome (AIDS) co infection with TB, a novel antitubercular drug is a prime need to effectively decrease the disease burde...
DESIGN AND DEVELOPMENT OF SOLID DISPERSION SYSTEM OF ZOLMITRIPTAN
Zolmitriptan is a potent anti-migraine drug. The bioavailability of Zolmitriptan is about 40% via oral dosage forms and problem arises from its low water solubility and dissolution rate. The present study deals with for...
ISOLATION AND EVALUATION OF DISINTEGRATING PROPERTIES OF BASELLA ALBA Linn. LEAF MUCILAGE IN TABLET FORMULATIONS
There are number of synthetic polymers are available in market for pharmaceutical formulations, but these synthetic polymers have certain disadvantages such as high cost, toxicity, environmental pollution during synthesi...
A RARE CASE REPORT OF GIANT CELL TUMOR IN THE BODY OF TALUS AND OUR MANAGEMENT
Giant cell tumor is described as neoplasm of undifferentiated mesenchymal stromal cells with presence of abundant, multi-nucleated giant cells. It is generally considered to be a benign tumor. Giant cell tumor rarely inv...
PREVALENCE OF ANTIBIOTIC SENSITIVITY AND RESISTANCE IN KLEBSIELLA PNEUMONIA ISOLATES FROM OMANI PATIENTS
Klebsiella pneumoniae is currently regarded as one of the most important opportunistic pathogen causing nosocomial and community infections naturally resistant to amino-penicillins and carboxy-penicillins due to extended...