Formulation and evaluation of mucoadhesive tablet of Clarithromycin
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
The present investigation concerns the development of mucoadhesive tablets of Clarithromycin which were designed to prolong the gastric residence time after oral administration. Matrix tablets of Clarithromycin were formulated using four mucoadhesive polymers namely Carbopol 974P, HPMC K15M, HPMC K4M, HPMCK100M carried out studies for weight variation, thickness, hardness, content uniformity, swelling index, mucoadhesive force and in vitro drug release. Formulation of C9 and C12 which were formulated by using polymers, HPMC K14M, HPMC K15M, HPMCK100M and Carbopol 974P provided controlled release of Clarithromycin over the period of 12 hrs. The cumulative % of drug release of formulation C9 (98.71%) respectively.
Authors and Affiliations
Mudedla Suresh, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Keywords
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