FORMULATION DEVELOPMENT AND EVALUATION OF GLICLAZIDE GEL USING WATER SOLUBLE SODIUM CARBOXY METHYL CELLULOSE POLYMER
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
High molecular weights water soluble homopolymer of Sodium Carboxy Methyl Cellulose (Sodium CMC) are reported to possess very high viscosity in low concentration, transparency, film forming properties and are useful in formation of gel. The Gliclazide gels were prepared by using different concentration of Sodium Carboxy Methyl Cellulose for topical drug delivery with an objective to increase transparency and spreadability. These preparations were with marketed Gliclazide gel. Spreadability and consistency of sodium CMC gel containing Gliclazide were 6.5g.cm/sec. The percent drug release was 97.11 and 98.66 from F9. Stability studies under accelerated condition showed satisfactory results. It can be concluded that sodium CMC gel containing Gliclazide showed good consistency, homogeneity, spreadability and stability and has wider prospect for topical preparations.
Authors and Affiliations
Vaibhav Kumar Mishra, Shashi Shekhar Tripathi
Keywords
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