FORMULATION AND EVALUATION OF ORAL CONTROLLED FLOATING TABLETS OF ANTI-ASTHAMATIC DRUG
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of the present research work is to formulate and evaluate oral controlled floating tablet of anti-asthmatic drug Terbutaline sulphate. The pre and post compression parameters have been studied and the results were found to be within the IP specification. The formulations F3 and F6 showed higher swelling index compared to others. In-vitro release rate studies showed that the maximum drug release was observed in F2 and F9 formulations up to 12 hrs. Optimized formula found to be stable at 45oC and 75% RH for a period of 3 month. FT-IR studies revealed that there was no interaction between drug and the polymers used. From the study it is evident that a promising controlled release floating tablets of Terbutaline sulfate can be developed to increase gastric residence time. Further detailed investigations are required to establish efficacy of these formulations and fix the required dose.
Authors and Affiliations
Sony Yellapu, Debjith Bhowmick, Harish Gopinath, Arvind Gurram, Anusha P
Keywords
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