FORMULATION AND EVALUATION OF ORAL THERMOREVESIBLE IN SITU GEL CONTAINING FLUCONAZOLE
Journal Title: Int J of Pharm Res & Analy - Year 2011, Vol 1, Issue 1
Abstract
The objective of this study was to formulate and evaluate in situ oral topical gels of Fluconazole based temperature induced systems for the treatment of oral condidiasis. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. The poor bioavailability and therapeutic response may be overcome by the use of mucoadhesive in situ gel forming systems that are applied as liquid into the buccal cavity and undergo a sol-gel transition which have good mucoadhesion with buccal mucus layers. Mucoadhesive systems were prepared by using polaxamer 188 combined with carbapol 934 to enhance the gel bio adhesion properties. Increase in the concentration of mucoadhesive agent enhanced the mucoadhesive force significantly. In vitro release of Fluconazole from the mucoadhesive system in simulated salivary fluid was influenced significantly by the properties and concentration of carbapol 934 showed to enhance bioavailability through its longer oral residence time and ability to sustain the release of the drug.
Authors and Affiliations
Maheswara Reddy C , Firoz S , Rajalakshmi. R , Ashok Kumar CK.
Keywords
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