FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDRHOCLORIDE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 2
Abstract
Diabetes is the major disease in the world. Metformin is used to treat the type II diabetes. Sustained tablets of metformin were prepared by using of different proportion of polymers, xanthan gum, and guar gum by wet granulation technique. The mixture of drug and excipients has shown good flow properties and tablets were proven that it has sufficient post compression properties. The sustained matrix tablets prepared with natural excipients are having better sustainability than marketed Metformin hydrochloride tablet that is prepared with synthetic polymers. The dissolution studies proved that our matrix tablets have shown 87.02% of drug release in 8hrs where as the marketed drug has shown 105.6% drug release in 8hrs.
Authors and Affiliations
A Madhusudhan Reddy, Ayesha Siddika, P Surya Bhaskara Rao, P Manasa, J Siddaiah, P Srinivasa Babu
Keywords
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