Formulation and evaluation of Terbutaline sulphate 5mg controlled release tablets for the treatment of nocturnal asthma
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 4
Abstract
The present work was aimed to design & characterize an oral dosage form to release Terbutaline sulphate following a programmed time period (pulsed release system). Pulsatile release tablet comprises a drug containing core and pH sensitive polymeric coating capable of delaying drug release and providing gastric resistance. The core tablets of Terbutaline sulphate were prepared for the treatment of nocturnal asthma. The core tablets were prepared by direct compression method using different disintegrating agents. The cores were coated with pH sensitive polymers (HPMCK4100, EC) at different coating levels to develop a suitable dosage form which should show minimum drug release in upper regions of gastrointestinal tract (GIT). Prepared tablets were characterized for various physical parameters such as hardness, thickness, weight variation disintegration test drug content and in-vitro drug release characteristics. All the parameters were found to be in the standard range. The dissolution of best formulation F3, have shown the lag phase of 5 hours at 10% coating level and almost complete drug release was achieved after 6 hours. The kinetic study data for best formulation followed zero order kinetics.
Authors and Affiliations
Kishore Babu, Dhatrika Sravanthi
Keywords
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