Formulation and In-vitro Evaluation of Fast Disintegrating Tablet of Eprosartan Mesylate
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
In the present work, fast dissolving tablets of Eprosartan Melysate were prepared by direct compression method with a view to enhance patient compliance. One super-disintegrants, viz., crospovidone use in different ratios with microcrystalline cellulose along with directly compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 13s), nine formulations batches were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 month) and drug-excipient interaction (IR spectroscopy). Among the nine promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t50% 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t50% 16.4 min). Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time. Keywords: Fast dissolving tablets, Eprosartan melysate , Crospovidone, Microcrystaline cellulose
Authors and Affiliations
S. B. Humane
Keywords
Related Articles
- EP ID EP487189
- DOI -
- Views 147
- Downloads 0
Recent advances in the treatment of Sepsis and septic shock; potential therapy based on biochemical evidence
The clinical syndrome sepsis and septic shock comprise of disorders which are increasingly common, potentially lethal, yet not clearly understood clinical syndromes. The rise in the incidence is well documented and thoug...
A COMPARATIVE EVALUATION OF FLEXURAL FATIGUE RESISTANCE OF PROTAPER NEXT AND PROFILE VORTEX: AN IN-VITRO STUDY.
Background: Introduction of nickel titanium file system for root canal therapy has changed the conventional approach but instrument fracture in curved and narrow root canal still remains a challenge for operator. Aim & o...
Drug Utilization Evaluation of Proton Pump Inhibitors in General Medicine Department of a Tertiary Care Teaching Hospital
Proton pump inhibitors (PPIs), antagonists of H+K+ ATPase, have been found as the most efficacious inhibitors of the gastric acid secretion. Prescribing PPIs is on the rise owing to polypharmacy and multiple co-morbid co...
COMPARATIVE IN VITRO ANALYSIS OF PHYSICOCHEMICAL PROPERTIES OF SOME ACECLOFENAC GENERIC TABLETS MARKETED IN BANGLADESH
Aceclofenac is a non-steroidal anti-inflammatory drug analog of diclofenac and works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandin (PG) and accountable for pain, swe...
FORMULATION AND EVALUATION OF FAST-DISINTEGRATING SUBLINGUAL TABLET OF VALSARTAN FOR THE TREATMENT OF HYPERTENSION
Objective: The purpose of the investigation is to formulate fast disintegrating sublingual tablet of Valsartan which is used in the treatment of hypertension to achieve faster onset of action. Materials: Crospovidone(CP)...