FORMULATION DEVELOPMENT AND EVALUATION OF CLARITHROMYCIN ORAL DOSAGE FORM AGAINST HELICOBACTER PYLORI INFECTION
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
There is keen interest in developing improved drug delivery systems to gastro intestinal tract for treatment of H. pylori induced peptic and duodenal ulcers, in the present study an attempt has been made to develop and evaluate gastroretentive matrix tablets of clarithromycin which were prepared by using Hydroxypropyl Methylcellulose K4M (HPMC K4M), Hydroxy Propyl Methyl Cellulose K15M (HPMC K15M) and Hydroxypropyl Methylcellulose K100M (HPMC K100M) with NaHCO3 as gas forming agent. Tablets were prepared by direct compression using directly compressible polymers such as HPMC K4M, HPMC K15M and HPMC K100M and were evaluated for drug - excipient compatibility, buoyancy test, tablet density, drug content and in-vitro release profile. Sodium bicarbonate was used for producing effervescent base for buoyancy of tablets. The release rate determined in 0.1 N HCL (pH 1.2) showed controlled release of drug following non-Fickian mechanism.
Authors and Affiliations
Pranjal Singh , Sanjoo Kumar, Easwari T. S. , V. K. Shukla , Saurabh Saraswat , Ramkumar Chaudhary
Keywords
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- EP ID EP108682
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