HEPATO PROTECTIVE EFFECT OF S-ADENOSYL-L-METHIONINE AGAINST ISONIAZID INDUCED HEPATITIS IN ANIMAL MODEL
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 41
Abstract
BACKGROUND S-Adenosyl-L-Methionine (SAM) protects liver cells in viral hepatitis and paracetamol-induced hepatic damage, etc. But, there are scanty data regarding hepatoprotective effect of SAM in isoniazid-induced liver damage. With this background, the present study is undertaken to assess the activity of SAM in isoniazid-induced liver damage in animal model. MATERIALS AND METHODS Hepatic injury was induced in albino rats by administering isoniazid (INH) at a dose of 54 mg/kg orally once daily for 30 days and served as the animal model of hepatitis. S-Adenosyl-L-Methionine (SAM) at dose of 48 mg/kg once daily was administered one hour prior to administration of INH to other group of rats (SAM pretreated group) for same 30 days duration and act as the test group. Silymarin 100 mg/kg was used as the standard hepatoprotective drug in the study. The liver enzymes and bilirubin level in serum were measured in above treatment groups and were compared statistically. Histopathology of liver was also compared among different groups. RESULTS There was a significant lowering of liver enzymes in SAM pretreated group in comparison to the model group of INH-induced hepatitis. Histological examination also showed protective effect on liver architecture in rats pretreated with SAM followed by INH. CONCLUSION The results of the animal study clearly demonstrated the hepatoprotective effects of SAM against isoniazid-induced hepatitis.
Authors and Affiliations
Suhasini Dehury, Kali Prasad Pattnaik, Asaranti Kar, Rajashree Samal, Kaumudi Pattnaik
Keywords
Related Articles
- EP ID EP219512
- DOI 10.18410/jebmh/2017/489
- Views 106
- Downloads 0
ATTENUATION OF CARDIOVASCULAR RESPONSES TO LARYNGOSCOPY AND INTUBATIONDEXMEDETOMIDINE VS. MAGNESIUM SULFATE
BACKGROUND Laryngoscopy and intubation are associated with cardiovascular changes like tachycardia, increase in blood pressure and pulmonary artery pressure and arrhythmias and ever since several methods have been sugges...
MR IMAGING IN INFECTIOUS SPONDYLITIS
BACKGROUND Spondylodiscitis is characterized by infection involving the intervertebral disc and adjacent vertebrae. MRI is the imaging modality of choice due to its very high sensitivity and specificity. It is also usefu...
A HISTOPATHOLOGICAL STUDY OF GALLBLADDER AFTER CHOLECYSTECTOMY
BACKGROUND Gall bladder disease is not an uncommon disorder. Most of the cases admitted in the hospitals require surgical intervention. Routine examination of the gall bladder after cholecystectomy shows different histop...
THE EFFICACY OF THERMO SPOT IN DETECTING NEONATAL HYPOTHERMIA COMPARED TO RECTAL TEMPERATURE
Hypothermia during the newborn period is widely regarded as a major contributory factor of significant morbidity and mortality in developing countries. High prevalence of hypothermia has been reported from countries with...
PREVALENCE OF HELICOBACTER PYLORI INFECTION IN GASTRIC CANCER IN PATIENTS ATTENDING A TERTIARY REFERRAL UNIT: A CROSS SECTIONAL STUDY
BACKGROUND The prevalence of gastric cancer is associated with several factors including geographical location, diet, and genetic background of the host. Helicobacter pylori infection is an important etiological factor f...