HISTOPATHOLOGICAL CHANGES INDUCED BY DESVENLAFAXINE IN CEREBELLUM OF SWISS ALBINO MICE
Journal Title: JOURNAL OF ANATOMICAL SCIENCES - Year 2017, Vol 25, Issue 1
Abstract
Introduction: Desvenlafaxine succinate is a novel salt form of isolated major active metabolite of venlafaxine. It has been classified as serotonin and nor-epinephrine reuptake inhibitor [SNRI] which increases their concentration in synaptic cleft by inhibiting reuptake pumps. The increased concentrations of these neurotransmitters are responsible for the effect of these drugs on brain and their anti-depressant property. Methods: Desvenlafaxine was administered to adult female Swiss albino mice in the dose of 80mg per kg body wt. by oral gavage. According to the duration of exposure of drug, mice were divided into following three groups. Group 1 (control) were treated with equivalent amount of tap water. In Group 2, mice were given drug for the first 6 days of gestation while in Group 3, they were treated from gestation days 1-18. Results: Cerebellum of group 2, showed alteration in the molecular layer in comparison to control. The laminar pattern was maintained but differentiating purkinje cells was not visible. Granular cell layer appeared to be more thickened as compared to control. Cerebellum of group 3, showed marked derangement of laminar pattern. Extensive vacuolation extending upto molecular level was seen. Plenty of pyknotic nuclei were present. Conclusion: Above changes suggest probable role of Desvenlafaxine in causing neurodegenerative and oxidative damage to cerebellum of Swiss albino mice.
Authors and Affiliations
Amrita Kumari
Keywords
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