HISTOLOGICAL PROFILE OF KIDNEY OF ALBINO RATS ON ORAL ADMINISTRATION OF SODIUM BENZOATE
Journal Title: JOURNAL OF ANATOMICAL SCIENCES - Year 2017, Vol 25, Issue 1
Abstract
Introduction: Sodium benzoate is a food preservative that is present in many food stuff as antimicrobials. The damaging effects of sodium benzoate on the kidney of albino rats were studied. Material & Methods: Forty albino rats randomly divided into four groups. Group I served as control which received distilled water. Group II, III & IV received 400mg/kg, 800mg/kg and 1200mg/kg of sodium benzoate respectively via intragastric route. After 30 days, the animals were sacrificed and kidney changes were observed by light microscope. Observations: We observed a general architectural derangement in the form of glomerular tufting, decreased Bowman’s space, dilatation of tubules, thickened basement membrane, cloudy swelling in tubules and whole of the kidney was found to be infiltrated with inflammatory cells.
Authors and Affiliations
Rashmi Kumari
Keywords
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