Histopathological Evaluation of Hyperplastic Endometrial Lesion based on New WHO classification
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 6
Abstract
Introduction: Endometrial hyperplasia is defined as an increase in the proliferation of endometrial glands relative to stroma, resulting in increased gland to stroma ratio. It is most commonly occurred due to unopposed oestrogen action. In recent past the most widely used system divided endometrial hyperplasia into four categories: simple hyperplasia without atypia; complex hyperplasia without atypia; simple atypical hyperplasia; complex atypical hyperplasia. Recently WHO collapse the four categories into two as non atypical hyperplasia and atypical hyperplasia (also referred as endometrial intraepithelial neoplasia). Aims: 1) To study comparison between the old and new WHO classification of endometrial hyperplasia. 2) To find out the age wise incidence of these lesions. 3) To estimate the incidence of benign and malignant lesions. Methods and Material: Retrospective study of cases of endometrial lesions diagnosed as endometrial hyperplasia in M.Y. hospital Indore during 10 year duration. The cases with endometrial hyperplasia were reclassified according to new WHO classification. Results: Among 600 cases of endometrial hyperplasia 94% cases are of non atypical hyperplasia while 6% cases are of atypical hyperplasia. Majority of the cases are between 41 to 60 year of age. 35% atypical hyperplasia cases they turned out to be malignant while only 0.5% cases without hyperplasia are converted to malignancy. Conclusions: Recently WHO classified endometrial hyperplasia as non atypical and atypical hyperplasia (endometrial intraepithelial neoplasia). It is better than old one as it represents an important simplification for clinical practice, particularly with regard to choice of treatment. Non atypical hyperplasia are treated conservatively while for atypical hyperplasia hysterectomies are done
Authors and Affiliations
Dr Shikha Ghanghoria
Keywords
Related Articles
- EP ID EP511786
- DOI -
- Views 62
- Downloads 0
Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats
Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with longterm da...
Effect of Green Bean Porridge Modisco on the Changes of Albumin Level among Under-five children with below the red line (Case Study at the Work Area of Randublatung Public Health Center, Blora District)
Below the red line condition does not indicate malnutrition, but it is a warning for confirmation and follow-up. Providing green bean porridge to under-five children on a regular basis is very good because it contains va...
The effects of microcytic hypochromic anemia on HBA1C in non-diabetics
Background: Hemoglobin A1c reflects patient’s glycemic status over previous 3 months. Iron deficiency anemia elevates hbA1c concentration independent of glycemia. This study aim to analyze effect of microcytic hypochromi...
Clinical Profile of Mortality due to fever with Thrombocytopenia during an Epidemic
Introduction: Many of the acute infective diseases which present as febrile thrombocytopenia during an epidemic have overlapping clinical profile and many of them may not have a definite diagnosis even at the time of pat...
The Reliability of the Cerebroplacental Ratio in the Prediction of Perinatal Outcome in IUGR Babies
Introduction: IUGR complicates up to 10%of pregnancies. Cerebroplacental ratio (CPR-MCA PI/ Umbilical artery PI) is emerging as a good tool for the prediction of perinatal adverse outcomes in IUGR babies. We attempted to...