Immunohistochemical Analysis & Correlation of EGFR and Ki-67 Expression Status with Clinicopathological Parameters in Head and Neck Squamous Cell Carcinomas: An Indian Perspective
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 5
Abstract
Head and neck squamous cell carcinoma (HNSCC) is sixth most common neoplasm worldwide and despite the progress made in the diagnosis and treatment, the survivalof these patients has not improved significantly[1] . Therefore a vigilant search for newer diagnostic and prognostic markers along with fresh molecular targets is required for the prevention & cure of HNSCCs and related tumors. Epidermal growth factor receptor (EGFR) and Ki 67 labelling index are reflective of continued cell growth and multiplication, thereby inducing tumorigenesis[2,3] . They are associated with disease progression, which in turn is a pointer towards tumor aggressiveness The importance of studying EGFR expression status lies in the fact that targeted therapy against this protein is available and has great potential [4] . However, extensive online search in indexed journals yielded very few results regarding the prognostic significance of Ki- 67 in HNSCC.
Authors and Affiliations
Dr Prerna Chadha
Keywords
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