Incidental detection of Plasma cell leukemia, A case report
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Plasma cell leukemia (PCL)is an uncommon, aggressive variant of lymphoproliferative disorder that may occur de novo (primary) or in association with multiple myeloma (secondary) . Primary PCL is a distinct clinicopathological entity with different cytogenetic abnormalities and molecular findings from multiple myeloma. Secondary PCL is seen in advanced myeloma. The diagnostic criteria are based on the percentage (>20%) and absolute number (2000/ml) of plasma cells in peripheral blood. Clinical course is aggressive with poor survival rate.We report a case of plasma cell leukemia detected incidentally when the patient was being evaluated for gastrointestinal symptoms. Peripheral blood showed >20 % plasma cells & absolute plasma cell count was much more than cut off limit of >2000/ml.Further bone marrow aspiration ,biopsy showed plasma cell precursors & sr electrophoresis showed M band , so diagnosis of secondary plasma cell leukemia was confirmed.PCL ,whether primary or secondry ,needs to be diagnosed early to initiate therapy immediately as it is known to have an aggressive clinical course & poor outcome .
Authors and Affiliations
Dr Prajna Das, Dr Sarojini Raman, Dr Kanakalata Dash
Keywords
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