Interaction of dexmedetomidine combined with sufentanil in the treatment of adenomyopathy by high-intensity focused ultrasound
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 12
Abstract
Objective To explore the interaction and compatibility optimization of dexmedetomidine combined with sufentanil in treatment of adenomyosis by high-intensity focused ultrasound (HIFU). Methods A total of 96 patients with adenomyosis who underwent HIFU treatment in Affiliated Hospital of Shandong Second Medical University from January 2023 to December 2023 were selected as the study subjects, and were randomly divided into 12 groups, with 8 cases in each group. The pain relief score (VAS score) and sedation score (Ramsay score) of the patient were recorded before surgery, 30 minutes after surgery began, and immediately after surgery. The changes of patients’ heart rate (HR), mean arterial pressure (MAP) and saturation of peripheral oxygen (SpO2) were monitored. The isobolographic analysis method was used to analyze the interaction between the two drugs at bispectral index for half of the patients falling asleep (BIS50). The response curve model was used to analyze the interaction law and optimal compatibility concentration range between dexmedetomidine and sufentanil, with the goal of 95% patients being satisfied with analgesia and Ramsay being effective in sedation. Results The response curve model showed that dexmedetomidine and sufentanil had a synergistic effect in the HIFU treatment of adenomyosis. When sufentanil concentration was 0.30, 0.40 and 0.45 μg/kg respectively, the optimal concentration range of dexmedetomidine was 0.53 to 0.65, 0.48 to 0.60 and 0.44 to 0.57 μg/kg respectively. Conclusion Dexmedetomidine and sufentanil have a synergistic effect on analgesia, and when used within the optimal compatibility concentration range, it can not only effectively relieve analgesia, but also reduce the occurrence of adverse reactions.
Authors and Affiliations
LI Guanrong, LI Min, WANG Ying, SUN Yingui
Keywords
Related Articles
- EP ID EP753806
- DOI 10.13429/j.cnki.cjcr.2024.12.010
- Views 28
- Downloads 0
Advances in the role of T cells in colorectal cancer and related therapies
T cells are closely associated with tumor development and the homeostasis of the tumor microenvironment (TME). The co-receptors of immune checkpoints on the surface of T cells collectively regulate immune responses and c...
Dose of remimazolam in painless gastroenteroscopy in elderly patients under bispectral index monitoring
"<b>Objective</b> To explore the appropriate initial dose of remimazolam for painless gastroenteroscopy in elderly patients based on bispectral index (BIS) monitoring. <b>Methods</b> A total of 165 elderly patients w...
Multimodal imaging in predicting left ventricular remodeling after PPCI in patients with acute ST-segment elevation myocardial infarction
Objective To investigate the predictive value of three-dimensional speckle tracking echocardiography (3D-STE), myocardial work (MW), and late gadolinium enhancement cardiac magnetic resonance (CMR-LGE) in left ventricula...
Construction of a predictive model for the severity of sepsis based on APACHE Ⅱ score, IL-6, and T lymphocyte subsets
Objective To construct a predictive model for the severity of sepsis using the Acute Physiology and Chronic Health EvaluationⅡ (APACHEⅡ) score, interleukin-6 (IL-6), and T lymphocyte subsets, and to evaluate the model's...
Advances in CT-based artificial intelligence techniques for lung nodule diagnosis
Lung cancer is one of the common malignancies worldwide. Lung nodules, defined as early stage manifestations, are critical for early detection and diagnosis to reduce mortality. In recent years, CT based artificial intel...