Investigating for Insulin Resistance and Type 2 Diabetes Mellitus in Obese Children
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2005, Vol 9, Issue 1
Abstract
The incidence and prevalence of type 2 diabetes mellitus within the childhood period has increased in the worldwide, particularly among obese children. The aim of this study was to investigate impaired glucose tolerance and insulin resistance in obese children. Thirty-six children (18 girls and 18 boys) aged between 7.4 and 17 years with a body mass index (BMI) > 95th percentile and referred to our hospital between 1998 and 2003. Control group consisted of 30 children (13 girls and 17 boys) aged between 7.2 and 17.8 years with a body mass index between 5th and 95th percentile. Fasting and oral glucose tolerance test (OGTT) 120th min serum glucose and insulin levels were measured. The glucose results were characterized according to the World Health Organizations criteria. Insulin resistance (IR) was defined by homeostasis model assessment (HOMA) as IRHOMA. Fasting glucose levels were in normal limits in all obese and control subjects. OGTT revealed that 9 of 36 obese children (25 %) had diagnosed impaired glucose tolerance and 2 children (6%) diabetes mellitus. Plasma glucose levels in OGTT were in normal limits in all control subjects. IRHOMA revealed insulin resistance in 17 of 36 obese children (47%) and significantly correlated puberty (r=0.418, p=0.0217), BMI (r=0.507, p=0.002), age (r=0.513, p=0.001), and insulin level at 120th min of OGTT (r=0.821, p<0.001). Overall mean IRHOMA in obese and control subjects were 4,1 ± 1.0 and 1,5 ± 0.9 , respectively. The difference of mean IRHOMA levels between obese and control subjects was significantly different (p<0,001). IRHOMA levels of 5 control subjects (16%) were above the level of cut-off point (2,5), however OGTT were normal in these subjects. In conclusion, the childhood obesity is one of the important risk factors for the early beginning of type 2 diabetes mellitus. An OGTT is more sensitive at identifying impaired glucose tolerance or diabetes mellitus than fasting glucose alone. Body-mass index (BMI) was strongest predictor of fasting and glucose stimulated insulin levels.
Authors and Affiliations
Enver Şimşek, Meltem Karabay, Şükrü Aras, Kenan Kocabay
Keywords
Related Articles
- EP ID EP84399
- DOI -
- Views 132
- Downloads 0
Comparison of Insulin Tolerance Test with Various Simple and Safe Methods in the Prediction of Insulin Sensitivity
In the measurement of insulin sensitivity, intravenous insulin tolerance test (IVITT) has been shown to have a high correlation with the euglycemic hyperinsulinemic clamp method. We compared IVITT with levels of plasma I...
Total Tiroidektomi Sonrası Gözlenen Hipoparatiroidizm<br /> İnsidensi ve Prediktif Faktörler
Amaç: Total tiroidektomi, günümüzde, malign olduğu kadar, benign tiroid hastalıklarında da kullanılan cerrahi yöntemdir. Postoperatif hipokalsemi, total tiroidektomilerden sonra karşımıza çıkabilecek major bir komplikasy...
Prevalence of Hepatitis C Virus Infection in Diabetic Patients
In order to evaluate the prevalence of hepatitis C virus (HCV) infection in diabetic patients, 13 type 1 and 106 type 2, a total of 119 diabetic patients were examined. Patients were analyzed for sex, type of diabetes, d...
Levothyroxine Replacement is Acceptable in Patients With Above the Upper Normal Range Lipid Profiles and Subclinical Hypothyroidism
Introduction: Subclinical hypothyroidism is a common disorder, particularly in middle-aged and elderly individuals. The aim of the present study was to determine the effect of L-thyroxine (LT4) substitution on serum lipi...
Graves Hastalarında Tiroid Nodülü Varlığı İleri Yaş ve Ilımlı Tirotoksikoz ile İlişkilidir
Amaç: Bu çalışmanın birincil amacı Graves Hastalığı’ndaki (GH) nodüler guatr belirleyicilerinin ortaya konmasıdır. Gereç ve Yöntemler: Çalışmaya 202 ardışık hasta dahil edildi (ortalama yaş: 45, 145 kadın). Tüm hastalar...