INVOLVEMENT OF OPIOIDERGIC SYSTEMS IN THE ANTIDEPRESSANT EFFECT OF 5- AMINOINDAZOLE
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 5, Issue 6
Abstract
Objectives: The present study was designed to investigate the anti-depressant activity of 5 – aminoindazole and the possible mechanism involved. Methods: Anti-depressant activity was evaluated in mice by employing forced swim test. The involvement of opioidergic system was investigated by using naloxone. Results: 5 - aminoindazole exhibited a significant and dose dependent reduction in period of immobility in the forced swim test. Pretreatment with naloxone attenuated the reduction in immobility period produced by 5 - aminoindazole. Conclusion: The investigated 5 - aminoindazole exhibited promising anti-depressant activity in animal models of depression. The participation of opioidergic mechanism in the antidepressant activity of 5 - aminoindazole was elucidated from the results.
Authors and Affiliations
Balida Mallikarjuna Rao| Department of Pharmacology, Vasant Rao Pawar Medical College Hospital and Research Center, Adagon, Nasik, Maharashtra, India, Jagan Nadipelly| Department of Pharmacology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Telangana, India, Ambareesha K| Department of Physiology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Telangana, India, Jyothinath Kothapalli| Department of Physiology, MNR Medical College and Hospital, Fasalwadi, Sangareddy, Medak, Telangana, India
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