Leu7Pro polymorphism of preproneuropeptide Y during a course of metabolic disease: functional analysis by gene ontology
Journal Title: Journal of Neurological Sciences-Turkish - Year 2007, Vol 24, Issue 3
Abstract
Background and Purpose: Neuropeptide Y (NPY), one of the most abundant neuropeptides found in the central nervous system (CNS), has been implicated in the regulation of many metabolism. Preproneuropeptide Y (PPNPY) is the signal peptide of the NPY. Effect of PPNPY Leu7Pro polymorphism on metabolic disorder is widely discussed and still controversial. Material and methods: To study the functional aberration in the human wild and mutate types of PPNPY in pathogenesis of type 2 diabetes is hard. Here, the author used a new gene ontology technology to predict the molecular function of human wild and mutate types of PPNPY. Results: Here, it can be seen that there is no functional difference between wild and mutate types of PPNPY. The common functions as Receptor binding, G-protein coupled receptor binding, hormone activity, neuropeptide hormone activity, G-protein coupled receptor activity, calcium channel regulator activity can be seen. Conclusion: This can support the null effect of this polymorphism in clinical findings of the patients. Therefore, this polymorphism might not be an important factor and have null effect in metabolic disorder. Finally, the author hereby recommends for a further study to analyze other know genetic variants within PPNPY gene to add more knowledge.
Authors and Affiliations
Viroj WIWANITKIT
Keywords
Related Articles
- EP ID EP112930
- DOI -
- Views 92
- Downloads 0
Harekete İlişkin Kortikal Potansiyallerin Alzheimer Hastalığında Nöröpsikolojik Testler ile Korelasyonu
Harekete ilişkin kortikal potansiyaller (HİKP) bir motor aktivitenin planlanmasını yansıtan yararlı bir yöntemdir. Hareketten önce frontal loblarda maksimum amplitüdde negatif kortikal potansiyal izlenir. Alzheimer hasta...
Clinical and Electrodiagnostic findings of n-Hexane Neuropathy
n-Hexane is an isomer of hexane and was identified as a peripheral neurotoxin in 1964. The solvents containing n-Hexane are used as cleaning agents in the printing, textile, furniture and shoemaking industries. Certain k...
Determination of Functional Regions of Human DAT For Labeling With Fluorescent Proteins For Further Use in FRET Studies
The dopamine transporter tightly regulates dopamine neurotransmission by the rapid uptake of released dopamine back into the presynaptic nerve terminal. This study aimed to determine functional positions for eCFP inserti...
Epilepsilerin Genetik Yönü ve İdyopatik Epilepsi Genetiğinde Son Gelişmeler
Epileptik sendromların temelinde kromozomal bozukluklar, tek gen defektleri ve büyük çoğunlukla da kompleks kalıtım gibi farklı genetik geçiş şekilleri yatmaktadır. Epilepsinin diğer nörolojik ve sistemik bulgulara eşlik...
Quantitative EEG Analysis in Patients With Severe Copd: Some Clues of Chronic Hypoxemic Degeneration
Objective: This cross-sectional clinical and electrophysiological study was performed in order to determine the electroencephalographic correlates of cognitive disturbances in patients with severe chronic obstructive pul...