Leucovorin-induced hypersensitivity reaction in acute lymphoblastic leukemia - A case report
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2017, Vol 7, Issue 9
Abstract
Leucovorin (LCV) acts as an essential coenzyme for nucleic acid synthesis and also it is an active metabolite of folic acid. LCV can be used to selectively “rescue” cells from the adverse effects of methotrexate (MTX). Here, we report a case of LCV-induced hypersensitivity reaction when used in combination with high dose MTX (HDMTX). We describe a 2-yearsold female baby diagnosed with B-cell acute lymphoblastic leukemia on chemotherapy with pediatric berlin-frankfurtmunster protocol; she is on HDMTX and injection LCV. After initiation of LCV (folinic acid) at 42 h she was noted to have hypersensitivity reaction. Despite reaction to LCV is uncommon, one should be aware of the reactions that can be caused by LCV.
Authors and Affiliations
Anju A Mathew, Chanshi Chandran, Raghuveer Prabhu, Remya Reghu
Keywords
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- EP ID EP291958
- DOI 10.5455/njppp.2017.7.0621407072017
- Views 82
- Downloads 0
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