Long-Term Effect of Chemoradiotherapy At Gastric Cancer on Pancreas
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 11
Abstract
Local or regional disease recurs or distant metastasis occur after resection in a significant proportion of those with gastric cancer.The reduce the risk of recurrence and mortality, adjuvant chemoradiotherapy has been proved to increase relapse-free survival and overall survival importantly.there is no knowledge about pancreas even it’s effected by most of the radiotherapy dose since it’s in close vicinity of stomach and dose levels which may adversely effect the pancreatic function are not defined. Therefore, the purpose of this study patients who referred to our clinic with opere gastric cancer and underwent adjuvant chemoradiotherapy were appraised prospectively and effects of pancreatic RT doses and outcomes were studied. The association among pancreatic functions, fasting blood glucose, glycosylated hemoglobin, insulin and amylase, pancreas volume and adjuvant chemoradiotherapy was determined.Before the initiation, after the first session and at the 1th, 3th, 6th, 12th and 24th months of radiotherapy, difference between serum Fasting blood glucose (p:0.209), insulin (p:0.276), HbA1c (p:0.528) and amylase levels (p:0.109) levels were not statistically significant but there is statistically significant decrease in pancreatic volume after treatment (p:0.002).Local or regional disease recurs or distant metastasis occur after surgery in a significant proportion of those with gastric cancer. Adjuvant chemoradiotherapy is able to prolong survival and decrease recurrence in operated gastric cancer patients. We could not identify any statistically significant finding related to pancreatic toxicity or its presentation on biochemical parameters except pancreas atrophy in 24 months period. Although we haven’t found any DMs in our sudy, it would be useful to continue the follow-up and perform more extensive studies
Authors and Affiliations
Mustafa Kandaz, Arif Çekiç, Ozan Cem Güler, Mehmet Arif Usta, Ali Güner, Serdar Türkyılmaz, Adnan Yöney
Keywords
Related Articles
- EP ID EP238860
- DOI 10.9790/0853-1611074551
- Views 130
- Downloads 0
Watch out- severe hyperthermia with misoprostol!
Misoprostol, used for the prevention and management of post partum haemorrhage, can have adverse effects and should be monitored carefully. We discuss a 30 year old primigravida who received misoprostol for post partum h...
Role of Video Assisted Thoracoscopic Surgery (VATS) in Diagnosis & Treatment of diseases of thoracic cavity
Introduction:VATS refers to the use of minimally invasive operative techniques employing endo-video guidance to accomplish thoracic surgical procedures previously requiring thoracotomy.. Patients&Methods:A prospective an...
Microbial Evaluation And Subchronic Toxicity Studies Of Ade & Ade Herbal Drug Formulated For Systemic Detoxification And Diuretic Agent.
OBJECTIVE: This study Evaluated Microbial Purity and Sub chronic toxicity studies of Ade and Ade Herbal Drug (AHD) in Wister’s rats. MATERIALS AND METHODS: Microbial purity was evaluated using appropriate diagnostic medi...
Soft Tissue Aesthetic: A Review Article
Aesthetics is an inseparable part of today’s dental treatment and has influenced the management of dental maladies in varying degrees for many years. In recent year clinicians and dentist’s aesthetic demand in dentistry...
Demographic AndClinico-Pathological Study of Salivary Neoplasms
Introduction:Salivary neoplasms (SN) are rare but not uncommoncondition. Benign and malignant tumors can arise from both epithelial and mesenchymal cells. Parotid gland is most commonly involved. Diagnosis and treatment...